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Gene and Protein Information ![]() |
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Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 6 | 1 | 664 | Xq28 | CNGA2 | cyclic nucleotide gated channel subunit alpha 2 | |
Mouse | 6 | 1 | 664 | X A7.3 | Cnga2 | cyclic nucleotide gated channel alpha 2 | 23 |
Rat | 6 | 1 | 664 | 16q12.4 | Cnga2 | cyclic nucleotide gated channel subunit alpha 2 | 12 |
Database Links ![]() |
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Alphafold | Q16280 (Hs), Q62398 (Mm), Q00195 (Rn) |
CATH/Gene3D | 2.60.120.10 |
ChEMBL Target | CHEMBL4523272 (Rn) |
Ensembl Gene | ENSG00000183862 (Hs), ENSMUSG00000005864 (Mm), ENSRNOG00000030119 (Rn) |
Entrez Gene | 1260 (Hs), 12789 (Mm), 25411 (Rn) |
Human Protein Atlas | ENSG00000183862 (Hs) |
KEGG Gene | hsa:1260 (Hs), mmu:12789 (Mm), rno:25411 (Rn) |
OMIM | 300338 (Hs) |
Pharos | Q16280 (Hs) |
RefSeq Nucleotide | NM_005140 (Hs), NM_007724 (Mm), NM_012928 (Rn) |
RefSeq Protein | NP_005131 (Hs), NP_031750 (Mm), NP_037060 (Rn) |
UniProtKB | Q16280 (Hs), Q62398 (Mm), Q00195 (Rn) |
Wikipedia | CNGA2 (Hs) |
Associated Proteins ![]() |
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Functional Characteristics ![]() |
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γ = 35 pS PCa/PNa = 6.8 |
Ion Selectivity and Conductance ![]() |
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Activators (Human) |
cyclic GMP > cyclic AMP (EC50 ~ 1 μM) |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gating inhibitors ![]() |
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gating Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The calmodulin binding site of CNGA2 is functionally silent in heteromeric CNG channels. Feedback-inhibition of the native olfactory CNG channel by calcium-calmodulin (CaM) is conferred by the CNGA4 and CNGB1b subunits [1,3-4,18-19,24]. |
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View species-specific channel blocker tables |
Tissue Distribution ![]() |
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Functional Assays ![]() |
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Physiological Functions ![]() |
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Phenotypes, Alleles and Disease Models ![]() |
Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Bradley J, Bönigk W, Yau KW, Frings S. (2004) Calmodulin permanently associates with rat olfactory CNG channels under native conditions. Nat Neurosci, 7 (7): 705-10. [PMID:15195096]
2. Bradley J, Li J, Davidson N, Lester HA, Zinn K. (1994) Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci USA, 91 (19): 8890-4. [PMID:7522325]
3. Bradley J, Reisert J, Frings S. (2005) Regulation of cyclic nucleotide-gated channels. Curr Opin Neurobiol, 15 (3): 343-9. [PMID:15922582]
4. Bradley J, Reuter D, Frings S. (2001) Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits. Science, 294 (5549): 2176-8. [PMID:11739960]
5. Brady JD, Rich ED, Martens JR, Karpen JW, Varnum MD, Brown RL. (2006) Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci USA, 103 (42): 15635-40. [PMID:17032767]
6. Brown RL, Haley TL, West KA, Crabb JW. (1999) Pseudechetoxin: a peptide blocker of cyclic nucleotide-gated ion channels. Proc Natl Acad Sci USA, 96 (2): 754-9. [PMID:9892706]
7. Brown RL, Lynch LL, Haley TL, Arsanjani R. (2003) Pseudechetoxin binds to the pore turret of cyclic nucleotide-gated ion channels. J Gen Physiol, 122 (6): 749-60. [PMID:14638933]
8. Brunet LJ, Gold GH, Ngai J. (1996) General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron, 17 (4): 681-93. [PMID:8893025]
9. Bönigk W, Bradley J, Müller F, Sesti F, Boekhoff I, Ronnett GV, Kaupp UB, Frings S. (1999) The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits. J Neurosci, 19 (13): 5332-47. [PMID:10377344]
10. Chen TY, Yau KW. (1994) Direct modulation by Ca(2+)-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature, 368 (6471): 545-8. [PMID:7511217]
11. Dean DM, Nguitragool W, Miri A, McCabe SL, Zimmerman AL. (2002) All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light?. Proc Natl Acad Sci USA, 99 (12): 8372-7. [PMID:12034887]
12. Dhallan RS, Yau KW, Schrader KA, Reed RR. (1990) Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature, 347 (6289): 184-7. [PMID:1697649]
13. Drescher MJ, Barretto RL, Chaturvedi D, Beisel KW, Hatfield JS, Khan KM, Drescher DG. (2002) Expression of subunits for the cAMP-sensitive 'olfactory' cyclic nucleotide-gated ion channel in the cochlea: implications for signal transduction. Brain Res Mol Brain Res, 98 (1-2): 1-14. [PMID:11834291]
14. Kaupp UB, Seifert R. (2002) Cyclic nucleotide-gated ion channels. Physiol Rev, 82 (3): 769-824. [PMID:12087135]
15. Kingston PA, Zufall F, Barnstable CJ. (1999) Widespread expression of olfactory cyclic nucleotide-gated channel genes in rat brain: implications for neuronal signalling. Synapse, 32 (1): 1-12. [PMID:10188632]
16. Liman ER, Buck LB. (1994) A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron, 13 (3): 611-21. [PMID:7522482]
17. Liu M, Chen TY, Ahamed B, Li J, Yau KW. (1994) Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel. Science, 266 (5189): 1348-54. [PMID:7526466]
18. Michalakis S, Reisert J, Geiger H, Wetzel C, Zong X, Bradley J, Spehr M, Hüttl S, Gerstner A, Pfeifer A et al.. (2006) Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. J Biol Chem, 281 (46): 35156-66. [PMID:16980309]
19. Munger SD, Lane AP, Zhong H, Leinders-Zufall T, Yau KW, Zufall F, Reed RR. (2001) Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science, 294 (5549): 2172-5. [PMID:11739959]
20. Nache V, Zimmer T, Wongsamitkul N, Schmauder R, Kusch J, Reinhardt L, Bönigk W, Seifert R, Biskup C, Schwede F et al.. (2012) Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels. Sci Signal, 5 (232): ra48. [PMID:22786723]
21. Pifferi S, Boccaccio A, Menini A. (2006) Cyclic nucleotide-gated ion channels in sensory transduction. FEBS Lett, 580 (12): 2853-9. [PMID:16631748]
22. Rosenbaum T, Gordon-Shaag A, Islas LD, Cooper J, Munari M, Gordon SE. (2004) State-dependent block of CNG channels by dequalinium. J Gen Physiol, 123 (3): 295-304. [PMID:14981138]
23. Ruiz ML, London B, Nadal-Ginard B. (1996) Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart. J Mol Cell Cardiol, 28 (7): 1453-61. [PMID:8841933]
24. Ungerer N, Mücke N, Broecker J, Keller S, Frings S, Möhrlen F. (2011) Distinct binding properties distinguish LQ-type calmodulin-binding domains in cyclic nucleotide-gated channels. Biochemistry, 50 (15): 3221-8. [PMID:21413724]
25. Zheng J, Zagotta WN. (2004) Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Neuron, 42 (3): 411-21. [PMID:15134638]