ChEMBL ligand: CHEMBL280164 (Apafant, WEB-2086, WEB 2086 BS, WEB-2086-BS)
PAF receptor/Platelet activating factor receptor in Human [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105] Platelet activating factor receptor in Guinea pig [ChEMBL: CHEMBL5136] [UniProtKB: P21556] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
PAF receptor/Platelet activating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105]
GtoPdb	-	-	7.5	pKi	-	-	-	J Biol Chem (1996) 271: 23298-303 [PMID:8798529]; Biochem Biophys Res Commun (1993) 190: 162-6 [PMID:8380690]
ChEMBL	Inhibition of [3H]PAF binding to dog platelets.	B	6.7	pIC50	200	nM	IC50	J Med Chem (1989) 32: 1820-1835 [PMID:2754709]
ChEMBL	In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.	B	6.7	pIC50	200	nM	IC50	J Med Chem (1991) 34: 1440-1446 [PMID:2016721]
ChEMBL	PAF-antagonist activity determined in dog platelets by PAF-binding assay	B	6.7	pIC50	200	nM	IC50	J Med Chem (1991) 34: 1209-1221 [PMID:2002463]
ChEMBL	Displacement of [3H]PAF from PAF receptor of human platelet membranes	B	7.03	pIC50	94	nM	IC50	J Med Chem (1998) 41: 1970-1979 [PMID:9599246]
ChEMBL	Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (1992) 2: 597-602
ChEMBL	Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.	F	7.4	pIC50	40	nM	IC50	J Med Chem (1991) 34: 457-461 [PMID:1671420]
Platelet activating factor receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5136] [UniProtKB: P21556]
ChEMBL	Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand	F	7.01	pKi	98.3	nM	Ki	J Med Chem (1994) 37: 2011-2032 [PMID:8027984]
ChEMBL	In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes	B	7.01	pKi	98	nM	Ki	J Med Chem (1992) 35: 2055-2061 [PMID:1317924]
ChEMBL	Competitive inhibition of Platelet activating factor receptor in rabbit-washed platelets	B	8.15	pKi	7.08	nM	Ki	J Med Chem (1995) 38: 2130-2137 [PMID:7783144]
ChEMBL	In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.	F	6.84	pIC50	146	nM	IC50	J Med Chem (1992) 35: 3115-3129 [PMID:1507200]
ChEMBL	Inhibition of PAF-induced platelet aggregation	F	7.04	pIC50	91	nM	IC50	J Med Chem (1993) 36: 2984-2997 [PMID:8411016]
ChEMBL	Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.	F	7.04	pIC50	91	nM	IC50	J Med Chem (1992) 35: 4118-4134 [PMID:1433215]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]