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ChEMBL ligand: CHEMBL439009 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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P2Y14 receptor/Purinergic receptor P2Y14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391] | ||||||||
ChEMBL | Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis | F | 6.17 | pEC50 | 670 | nM | EC50 | J Med Chem (2007) 50: 2030-2039 [PMID:17407275] |
ChEMBL | Agonist activity at human P2Y14 receptor expressed in human COS7 cells | F | 6.17 | pEC50 | 670 | nM | EC50 | Bioorg Med Chem (2009) 17: 5298-5311 [PMID:19502066] |
GtoPdb | - | - | 7 | pEC50 | - | - | - | J Biol Chem (2000) 275: 10767-71 [PMID:10753868] |
P2Y14 receptor in Mouse [GtoPdb: 330] [UniProtKB: Q9ESG6] | ||||||||
GtoPdb | - | - | 7.6 | pEC50 | - | - | - | Genomics (2001) 78: 124-8 [PMID:11735218] |
P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881] | ||||||||
GtoPdb | - | - | 7.1 | pEC50 | - | - | - | Genomics (2001) 78: 124-8 [PMID:11735218] |
GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304] | ||||||||
GtoPdb | [35S]GTPγS binding to 1321N1 cell membranes expressing hGPR17. | - | 8.92 | pEC50 | 1.2 | nM | EC50 |
Br J Pharmacol (2010) 159: 1092-105 [PMID:20148890]; EMBO J (2006) 25: 4615-27 [PMID:16990797] |
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65] | ||||||||
GtoPdb | - | - | 7.17 | pEC50 | 68 | nM | EC50 | PLoS ONE (2008) 3: e3579 [PMID:18974869] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]