MRS7799 [Ligand Id: 14223] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2181976 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| ChEMBL | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | B | 6.18 | pKi | >666 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| ChEMBL | Displacement of [3H] DPCPX from human adenosine A1 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 6.79 | pKi | 162 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A1 receptor/Adenosine A1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612] | ||||||||
| ChEMBL | Displacement of [3H] DPCPX from mouse adenosine A1 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 6.39 | pKi | 411 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Displacement of [3H] DPCPX from rat adenosine A1 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 6.48 | pKi | 333 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter | B | 6.08 | pKi | >826 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| ChEMBL | Displacement of [3H] ZM241385 from human adenosine A2A receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 6.92 | pKi | 121 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A2A receptor/Adenosine A2a receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2115] [GtoPdb: 19] [UniProtKB: Q60613] | ||||||||
| ChEMBL | Displacement of [3H] ZM241385 from mouse adenosine A2A receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 6.08 | pKi | 830 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
| ChEMBL | Displacement of [3H] ZM241385 from rat adenosine A2A receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 5.94 | pKi | 1150 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Displacement of [3H] DPCPX from human adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 6.64 | pKi | 230 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A2B receptor/Adenosine A2b receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2237] [GtoPdb: 20] [UniProtKB: Q60614] | ||||||||
| ChEMBL | Displacement of [3H] DPCPX from mouse adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 6.72 | pKi | 189 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A2B receptor/Adenosine A2b receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2592] [GtoPdb: 20] [UniProtKB: P29276] | ||||||||
| ChEMBL | Displacement of [3H] DPCPX from rat adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 6.79 | pKi | 163 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| GtoPdb | - | - | 9.26 | pKd | 0.55 | nM | Kd | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| ChEMBL | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 8.78 | pKi | 1.65 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| ChEMBL | Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | B | 9.44 | pKi | 0.36 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| A3 receptor/Adenosine A3 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075269] [GtoPdb: 21] [UniProtKB: Q61618] | ||||||||
| ChEMBL | Displacement of [125I]I-AB-MECA from mouse adenosine A3 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 8.02 | pKi | 9.61 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
| ChEMBL | Displacement of [125I]I-AB-MECA from rat adenosine A3 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay | B | 8.07 | pKi | 8.53 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| ChEMBL | Displacement of [125I]I-AB-MECA from human rat adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | B | 8.8 | pKi | 1.6 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| ChEMBL | Binding affinity to human M5 receptor by radioligand binding assay | B | 5.43 | pKi | 3700 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity to human 5-HT2A receptor by radioligand binding assay | B | 6.02 | pKi | 960 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Binding affinity to human 5-HT2C receptor by radioligand binding assay | B | 6.1 | pKi | 790 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
