compound 17b [PMID: 19639995] [Ligand Id: 14146] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL564392 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FPR1/fMet-Leu-Phe receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462] | ||||||||
| ChEMBL | Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay | F | 5.49 | pEC50 | 3200 | nM | EC50 | J Med Chem (2009) 52: 5044-5057 [PMID:19639995] |
| ChEMBL | Agonist activity at human FPR1 | F | 5.49 | pEC50 | 3200 | nM | EC50 | Eur J Med Chem (2024) 265: 115989-115989 [PMID:38199163] |
| ChEMBL | Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay | F | 6.1 | pEC50 | 800 | nM | EC50 | J Med Chem (2009) 52: 5044-5057 [PMID:19639995] |
| ChEMBL | Agonist activity at FPR1 in human neutrophiles by chemotaxis assay | F | 6.1 | pEC50 | 800 | nM | EC50 | J Med Chem (2009) 52: 5044-5057 [PMID:19639995] |
| GtoPdb | Potency for intracellular calcium mobilization | - | 6.1 | pEC50 | 800 | nM | EC50 |
Eur J Med Chem (2024) 265: 115989 [PMID:38199163]; J Med Chem (2009) 52: 5044-57 [PMID:19639995] |
| FPR2/N-formyl peptide receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4227] [GtoPdb: 223] [UniProtKB: P25090] | ||||||||
| ChEMBL | Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay | F | 6.22 | pEC50 | 600 | nM | EC50 | J Med Chem (2009) 52: 5044-5057 [PMID:19639995] |
| ChEMBL | Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay | F | 6.22 | pEC50 | 600 | nM | EC50 | J Med Chem (2009) 52: 5044-5057 [PMID:19639995] |
| ChEMBL | Agonist activity at human FPR2 | F | 7.3 | pEC50 | >50 | nM | EC50 | Eur J Med Chem (2024) 265: 115989-115989 [PMID:38199163] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
