GR 127935 [Ligand Id: 14] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL15928 (GR-127935)
  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
  • This target only has 1 pki data point
  • 5
1 CHEMBL15928_lig_chart_1 Delta opioid receptor Human
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
  • 5
2 CHEMBL15928_lig_chart_2 Dopamine D1 receptor Human
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • 5
3 CHEMBL15928_lig_chart_3 Dopamine D2 receptor Human
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • 5
4 CHEMBL15928_lig_chart_4 Dopamine D3 receptor Human
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • 5
5 CHEMBL15928_lig_chart_5 Dopamine D4 receptor Human
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  • D5 receptor/Dopamine D5 receptor in Human [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
  • This target only has 1 pki data point
  • 5
6 CHEMBL15928_lig_chart_6 Dopamine D5 receptor Human
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  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
  • This target only has 1 pki data point
  • 5
7 CHEMBL15928_lig_chart_7 Histamine H1 receptor Human
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  • κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
  • This target only has 1 pki data point
  • 5
8 CHEMBL15928_lig_chart_8 Kappa opioid receptor Human
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  • μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
  • This target only has 1 pki data point
  • 5
9 CHEMBL15928_lig_chart_9 Mu opioid receptor Human
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • 5.5
10 CHEMBL15928_lig_chart_10 Muscarinic acetylcholine receptor M1 Human
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • 5.5
11 CHEMBL15928_lig_chart_11 Muscarinic acetylcholine receptor M2 Human
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • 5.5
12 CHEMBL15928_lig_chart_12 Muscarinic acetylcholine receptor M3 Human
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  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
  • This target only has 1 pki data point
  • 5
13 CHEMBL15928_lig_chart_13 Muscarinic acetylcholine receptor M4 Human
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
  • This target only has 1 pki data point
  • 5
14 CHEMBL15928_lig_chart_14 Muscarinic acetylcholine receptor M5 Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
  • 6.5
15 CHEMBL15928_lig_chart_15 Serotonin 1a (5-HT1a) receptor HumanRat
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
  • 8.5
16 CHEMBL15928_lig_chart_16 Serotonin 1b (5-HT1b) receptor HumanRat
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Mouse [ChEMBL: CHEMBL4297] [GtoPdb: 3] [UniProtKB: Q61224]
  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Rat [ChEMBL: CHEMBL5450] [GtoPdb: 3] [UniProtKB: P28565]
  • Serotonin 1d (5-HT1d) receptor in Guinea pig [ChEMBL: CHEMBL2304407] [UniProtKB: Q60484]
  • 8.5
17 CHEMBL15928_lig_chart_17 Serotonin 1d (5-HT1d) receptor HumanMouseRatGuinea pig
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • 7.8
18 CHEMBL15928_lig_chart_18 Serotonin 2a (5-HT2a) receptor Human
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • 6.99
19 CHEMBL15928_lig_chart_19 Serotonin 2c (5-HT2c) receptor Human
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20 CHEMBL15928_lig_chart_20 Serotonin 3 (5-HT3) receptor Human
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  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
  • This target only has 1 pki data point
  • 5
21 CHEMBL15928_lig_chart_21 Serotonin 4 (5-HT4) receptor Human
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • 5.4
22 CHEMBL15928_lig_chart_22 Serotonin 6 (5-HT6) receptor Human
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • This target only has 1 pki data point
  • 5
23 CHEMBL15928_lig_chart_23 Serotonin 7 (5-HT7) receptor Human
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 0 pki data point
  • 0
24 CHEMBL15928_lig_chart_24 Serotonin transporter Human
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  • 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
  • This target only has 1 pki data point
  • 5.4
25 CHEMBL15928_lig_chart_25 5-ht1e receptor Human
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  • 5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
  • This target only has 1 pki data point
  • 7.2
26 CHEMBL15928_lig_chart_26 5-HT1F receptor Human
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
  • This target only has 1 pki data point
  • 6.2
27 CHEMBL15928_lig_chart_27 5-HT2B receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL Affinity towards cloned Opioid receptor delta 1 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL Binding affinity against dopamine receptor D1 B 5 pKi <10000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
ChEMBL Affinity towards cloned Dopamine receptor D1 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity against dopamine D2 receptor B 5 pKi <10000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
ChEMBL Affinity towards cloned Dopamine receptor D2 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Binding affinity against dopamine D3 receptor B 5 pKi <10000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
ChEMBL Affinity towards cloned Dopamine receptor D3 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity against dopamine D4 receptor B 5 pKi <10000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
ChEMBL Affinity towards cloned Dopamine receptor D4 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
ChEMBL Affinity towards cloned Dopamine receptor D5 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL Affinity towards cloned Histamine H1 receptor B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL Affinity towards cloned Opioid receptor kappa 1 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL Affinity towards cloned Opioid receptor mu 1 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL Affinity towards cloned Muscarinic acetylcholine receptor M1 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
ChEMBL Binding affinity against muscarinic M1 receptor B 6 pKi <1000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL Affinity towards cloned Muscarinic acetylcholine receptor M2 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
ChEMBL Binding affinity against muscarinic M2 receptor B 6 pKi <1000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL Affinity towards cloned Muscarinic acetylcholine receptor M3 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
ChEMBL Binding affinity against muscarinic M3 receptor B 6 pKi <1000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL Affinity towards cloned Muscarinic acetylcholine receptor M4 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL Affinity towards cloned Muscarinic acetylcholine receptor M5 B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL In vitro binding affinity towards cloned human 5-HT1A receptor using [3H]5-carboximidotryptamine as radioligand B 7.1 pKi 80 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
ChEMBL Affinity for 5-hydroxytryptamine 1A receptor subtype B 7.14 pKi 72 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 3183-3188
ChEMBL Affinity towards cloned human 5-hydroxytryptamine 1A receptor B 7.15 pKi 70 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
GtoPdb - - 7.2 pKi - - - J Med Chem (1997) 40: 3974-8 [PMID:9397179];
Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus with [3H]8-OH-DPAT B 6.5 pKi 316.23 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
ChEMBL Inhibition activity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using radio binding assays B 6.37 pIC50 425 nM IC50 J. Med. Chem. (2000) 43: 517-525 [PMID:10669578]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand. B 6.44 pIC50 360 nM IC50 J. Med. Chem. (2000) 43: 1149-1157 [PMID:10737747]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL In vitro binding affinity towards cloned human 5-HT1B receptor using [3H]5-carboximidotryptamine as radioligand B 8.37 pKi 4.31 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
ChEMBL Binding affinity for human 5-hydroxytryptamine 1B receptor B 9 pKi 1 nM Ki J. Med. Chem. (1998) 41: 1218-1235 [PMID:9548813]
GtoPdb - - 9.2 pKi - - - Eur J Pharmacol (1999) 380: 171-81 [PMID:10513577]
GtoPdb - - 9.8 pKi - - - J Med Chem (1997) 40: 3974-8 [PMID:9397179];
Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567];
Br J Pharmacol (1998) 125: 202-8 [PMID:9776361];
Eur J Pharmacol (1996) 314: 365-72 [PMID:8957260];
J Med Chem (1998) 41: 1218-35 [PMID:9548813]
ChEMBL Affinity for 5-hydroxytryptamine 1B receptor subtype B 9.85 pKi 0.14 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 3183-3188
ChEMBL Affinity towards cloned human 5-hydroxytryptamine 1B receptor B 9.85 pKi 0.14 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindolol B 8.5 pKi 3.16 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
ChEMBL Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay B 8.8 pIC50 1.6 nM IC50 J. Med. Chem. (2000) 43: 517-525 [PMID:10669578]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand. B 8.8 pIC50 1.6 nM IC50 J. Med. Chem. (2000) 43: 1149-1157 [PMID:10737747]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand B 7.91 pKi 12.3 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
ChEMBL Binding affinity for human 5-hydroxytryptamine 1D receptor B 8.6 pKi 2.51 nM Ki J. Med. Chem. (1998) 41: 1218-1235 [PMID:9548813]
GtoPdb - - 8.6 pKi - - - Mol Pharmacol (1996) 50: 1567-80 [PMID:8967979]
ChEMBL Binding affinity against 5-hydroxytryptamine 1D receptor alpha B 8.9 pKi 1.26 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
GtoPdb - - 9.1 pKi - - - J Med Chem (1997) 40: 3974-8 [PMID:9397179];
Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567];
Br J Pharmacol (1998) 125: 202-8 [PMID:9776361];
Eur J Pharmacol (1996) 314: 365-72 [PMID:8957260];
J Med Chem (1998) 41: 1218-35 [PMID:9548813]
ChEMBL Affinity for 5-hydroxytryptamine 1D receptor subtype B 9.15 pKi 0.7 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 3183-3188
ChEMBL Affinity towards cloned human 5-hydroxytryptamine 1D receptor B 9.15 pKi 0.7 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
ChEMBL Binding affinity against 5-hydroxytryptamine 1D receptor beta B 9.9 pKi 0.13 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
ChEMBL Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay B 7.28 pIC50 52 nM IC50 J. Med. Chem. (2000) 43: 517-525 [PMID:10669578]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4297] [GtoPdb: 3] [UniProtKB: Q61224]
ChEMBL Tested for 5-hydroxytryptamine receptor uptake F 5 pKi <10000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5450] [GtoPdb: 3] [UniProtKB: P28565]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand. B 7.28 pIC50 53 nM IC50 J. Med. Chem. (2000) 43: 1149-1157 [PMID:10737747]
Serotonin 1d (5-HT1d) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304407] [UniProtKB: Q60484]
ChEMBL In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine B 8.5 pKi 3.16 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL In vitro binding affinity towards cloned human 5-HT2A receptor using [3H]5-carboximidotryptamine as radioligand B 7.37 pKi 42.7 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2A receptor B 7.8 pKi 15.85 nM Ki J. Med. Chem. (1998) 41: 1218-1235 [PMID:9548813]
GtoPdb - - 7.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567];
J Med Chem (1998) 41: 1218-35 [PMID:9548813]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL In vitro binding affinity towards cloned human 5-HT2C receptor using [3H]5-carboximidotryptamine as radioligand B 6.98 pKi 105 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
GtoPdb - - 7 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377374373376375] [UniProtKB: A5X5Y0O95264P46098Q70Z44Q8WXA8]
ChEMBL Binding affinity against the 5-hydroxytryptamine 3 receptor B 5.2 pKi 6309.57 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL Binding affinity against 5-hydroxytryptamine 4 receptor B 5 pKi <10000 nM Ki J. Med. Chem. (1994) 37: 2253-2257 [PMID:8057272]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL In vitro binding affinity towards cloned human 5-HT6 receptor using [3H]5-carboximidotryptamine as radioligand B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
GtoPdb - - 5.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4786-4789 [PMID:16143528]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Inhibition of 5-hydroxytryptamine reuptake B 6 pIC50 1000 nM IC50 J. Med. Chem. (2000) 43: 517-525 [PMID:10669578]
5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
GtoPdb - - 5.4 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]
5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
GtoPdb - - 7.2 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567];
Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb - - 6.2 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 312-20 [PMID:9303567]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]