BAY-277 [Ligand Id: 13974] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5465171 (BAY_277, BAY-277) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of H3 | B | 7.14 | pKi | 72.84 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of H3 | B | 7.14 | pKi | 72.84 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of H3 | B | 7.15 | pKi | 70.79 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of H3 | B | 7.15 | pKi | 70.79 | nM | Ki | Data for DCP probe BAY-277 |
| Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3922] [GtoPdb: 1573] [UniProtKB: P50579] | ||||||||
| ChEMBL | 2D HUVEC cells proliferation assay | F | 7.92 | pIC50 | 12 | nM | IC50 | Data for DCP probe BAY-277 |
| ChEMBL | METAP2 biochemical assay (human) | B | 8.24 | pIC50 | 5.8 | nM | IC50 | Data for DCP probe BAY-277 |
| GtoPdb | - | - | 8.24 | pIC50 | 5.8 | nM | IC50 | Overview for BAY-277 a degrader of METAP2. thesgc.org |
| Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075272] [GtoPdb: 1573] [UniProtKB: O08663] | ||||||||
| ChEMBL | METAP2 biochemical assay (mouse) | B | 8.23 | pIC50 | 5.9 | nM | IC50 | Data for DCP probe BAY-277 |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of M1 | B | 5.78 | pKi | 1670.44 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M1 | B | 5.78 | pKi | 1670.44 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M1 | B | 5.78 | pKi | 1659.59 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M1 | B | 5.78 | pKi | 1659.59 | nM | Ki | Data for DCP probe BAY-277 |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of M2 | B | 6.17 | pKi | 676.76 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M2 | B | 6.17 | pKi | 676.76 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M2 | B | 6.17 | pKi | 676.08 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M2 | B | 6.17 | pKi | 676.08 | nM | Ki | Data for DCP probe BAY-277 |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of M3 | B | 5.65 | pKi | 2262.9 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M3 | B | 5.65 | pKi | 2262.9 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M3 | B | 5.68 | pKi | 2089.3 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M3 | B | 5.68 | pKi | 2089.3 | nM | Ki | Data for DCP probe BAY-277 |
| M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of M4 | B | 6.2 | pKi | 631.53 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M4 | B | 6.2 | pKi | 631.53 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M4 | B | 6.21 | pKi | 616.6 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M4 | B | 6.21 | pKi | 616.6 | nM | Ki | Data for DCP probe BAY-277 |
| M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of M5 | B | 6.25 | pKi | 567.76 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M5 | B | 6.25 | pKi | 567.76 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M5 | B | 6.25 | pKi | 562.34 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of M5 | B | 6.25 | pKi | 562.34 | nM | Ki | Data for DCP probe BAY-277 |
| σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of Sigma 2 | B | 6.06 | pKi | 866.55 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of Sigma 2 | B | 6.06 | pKi | 866.55 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of Sigma 2 | B | 6.08 | pKi | 831.76 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of Sigma 2 | B | 6.08 | pKi | 831.76 | nM | Ki | Data for DCP probe BAY-277 |
| DAT/Sodium-dependent dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of DAT | B | 5.43 | pKi | 3731.65 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of DAT | B | 5.43 | pKi | 3731.65 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of DAT | B | 5.47 | pKi | 3388.44 | nM | Ki | Data for DCP probe BAY-277 |
| ChEMBL | GPCRScan assay: inhibition of DAT | B | 5.47 | pKi | 3388.44 | nM | Ki | Data for DCP probe BAY-277 |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
