perzebertinib [Ligand Id: 13741] activity data from GtoPdb

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  • epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
Created with Highcharts 10.3.3ValuesChart context menuepidermal growth factor receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • erb-b2 receptor tyrosine kinase 2 in Human [GtoPdb: 2019] [UniProtKB: P04626]
Created with Highcharts 10.3.3ValuesChart context menuerb-b2 receptor tyrosine kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb Inhibition of wt EGFR phosphorylation in NCI H838 cells - 7.92 pIC50 12 nM IC50 WO2020057511A1. Quinazoline derivatives as antitumor agents (2020)
erb-b2 receptor tyrosine kinase 2 in Human [GtoPdb: 2019] [UniProtKB: P04626]
GtoPdb Inhibition of HER2 phosphorylation in BT474 cells - 8.02 pIC50 9.5 nM IC50 WO2020057511A1. Quinazoline derivatives as antitumor agents (2020)

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.