tulmimetostat [Ligand Id: 12615] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL5095231 (Cpi 0209, CPI-0209, CPI0209, Tulmimetostat) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| enhancer of zeste 2 polycomb repressive complex 2 subunit in Human [GtoPdb: 2654] [UniProtKB: Q15910] | ||||||||
| GtoPdb | Binding inhibition constant for EZH2 | - | 10.96 | pKi | 0.01 | nM | Ki | US20220257577A1. Ezh2 inhibition in combination therapies for the treatment of cancers (2022) |
| GtoPdb | Inhibition of catalytic activity of wild-type EZH2-containing PRC2 complex in a biochemical assay | - | 10.7 | pIC50 | 0.02 | nM | IC50 | US20220257577A1. Ezh2 inhibition in combination therapies for the treatment of cancers (2022) |
| enhancer of zeste 1 polycomb repressive complex 2 subunit in Human [GtoPdb: 2835] [UniProtKB: Q92800] | ||||||||
| GtoPdb | Inhibition of catalytic activity of wild-type EZH1-containing PRC2 complex in a biochemical assay | - | 10.22 | pIC50 | 0.06 | nM | IC50 | US20220257577A1. Ezh2 inhibition in combination therapies for the treatment of cancers (2022) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
