biricodar [Ligand Id: 11741] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL350775 (Biricodar) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795] | ||||||||
| ChEMBL | Inhibitory activity against P-glycoprotein (Pgp) using accumulation assay for Pgp expressing EMT6/AR1.0 cells. | F | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 571-574 [PMID:11844674] |
| ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527] | ||||||||
| ChEMBL | Inhibition of multidrug resistance associated protein type 1 (MRP1) assayed by an accumulation assay in COR.L23/R cells | F | 5.29 | pIC50 | 5180 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 571-574 [PMID:11844674] |
| GtoPdb | - | - | 5.29 | pIC50 | 5180 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 571-4 [PMID:11844674] |
| FKBP prolyl isomerase 1A/Peptidyl-prolyl cis-trans isomerase FKBP1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] | ||||||||
| ChEMBL | Binding affinity to FKBP12 by fluorescence polarization assay | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| FKBP prolyl isomerase 4/Peptidyl-prolyl cis-trans isomerase FKBP4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] | ||||||||
| ChEMBL | Binding affinity to FKBP52 FK1 domain by fluorescence polarization assay | B | 5.13 | pIC50 | 7370 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451] | ||||||||
| ChEMBL | Binding affinity to FKBP51 FK1 domain by fluorescence polarization assay | B | 5.07 | pIC50 | 8520 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| ABCB1 in Human [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| GtoPdb | - | - | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 571-4 [PMID:11844674] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
