ChEMBL ligand: CHEMBL42126 (Piclamilast, RP-73041, RP 73401, RP-73401, RP73401, RPR-73401)
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] Phosphodiesterase 4A in Pig [ChEMBL: CHEMBL3333] [UniProtKB: O77823] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
GtoPdb	Inhibition of rolipram binding to human PDE4	-	8.82	pKi	1.5	nM	Ki	J Med Chem (1994) 37: 1696-703 [PMID:8201604]
ChEMBL	Inhibition of human recombinant PDE4A	B	8.4	pIC50	4	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).	B	8.8	pIC50	1.6	nM	IC50	J Med Chem (1998) 41: 266-270 [PMID:9464356]
Phosphodiesterase 4A in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3333] [UniProtKB: O77823]
ChEMBL	Inhibitory potency against pig aortic PDE IV	B	9	pIC50	1	nM	IC50	J Med Chem (1994) 37: 1696-1703 [PMID:8201604]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human recombinant PDE4B	B	8.52	pIC50	3	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2010) 20: 2928-2932 [PMID:20378348]
ChEMBL	Inhibition of recombinant human Phosphodiesterase 4B	B	9	pIC50	1	nM	IC50	J Med Chem (1998) 41: 266-270 [PMID:9464356]
ChEMBL	Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes	B	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem Lett (2002) 12: 653-658 [PMID:11844693]
ChEMBL	Inhibition of human PDE4B	B	10.39	pIC50	0.04	nM	IC50	Bioorg Med Chem (2010) 18: 2204-2218 [PMID:20188577]
ChEMBL	Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method	B	10.39	pIC50	0.04	nM	IC50	J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
ChEMBL	Inhibition of human PDE4B by scintillation counting method	B	10.39	pIC50	0.04	nM	IC50	J Med Chem (2020) 63: 10594-10617 [PMID:32255344]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
ChEMBL	Inhibition of human recombinant PDE4C	B	7.85	pIC50	14	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4C	B	8.42	pIC50	3.8	nM	IC50	J Med Chem (1998) 41: 266-270 [PMID:9464356]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL	Inhibition of human recombinant PDE4D	B	8.7	pIC50	2	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	In vitro inhibitory activity on unpurified recombinant Phosphodiesterase 4D	B	9.1	pIC50	0.8	nM	IC50	J Med Chem (1998) 41: 266-270 [PMID:9464356]
ChEMBL	Inhibition of human PDE4D	B	10.68	pIC50	0.02	nM	IC50	Bioorg Med Chem (2010) 18: 2204-2218 [PMID:20188577]
ChEMBL	Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method	B	10.68	pIC50	0.02	nM	IC50	J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
ChEMBL	Inhibition of human PDE4D by scintillation counting method	B	10.68	pIC50	0.02	nM	IC50	J Med Chem (2020) 63: 10594-10617 [PMID:32255344]
ChEMBL	Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubated for 30 mins by scintillation counting method	B	10.7	pIC50	0.02	nM	IC50	EP-2674161-A1. FMO3 inhibitors for treating pain (2013)

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]