toceranib [Ligand Id: 11619] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL13608 (Palladia, PHA-291639, Toceranib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of epidermal growth factor receptor (EGF-R) | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| GtoPdb | - | - | 6.3 | pKi | 500 | nM | Ki | Blood (2002) 100: 585-93 [PMID:12091352] |
| ChEMBL | Inhibition of Fibroblast growth factor receptor 1 | B | 5.41 | pIC50 | 3900 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha in Human [GtoPdb: 1804, 1803] [UniProtKB: P09619, P16234] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | 5 | nM | Ki | Blood (2002) 100: 585-93 [PMID:12091352] |
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096980] [GtoPdb: 1804, 1803] [UniProtKB: P05622, P26618] | ||||||||
| ChEMBL | Inhibition of Platelet-derived growth factor induced 3T3 cell proliferation | F | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| ChEMBL | Inhibition of PDGF-induced BrdU incorporation in 3T3 cells | F | 7.15 | pIC50 | <70 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Inhibition of Platelet-derived growth factor receptor beta (PDGF-Rbeta) | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| GtoPdb | - | - | 8.22 | pKi | 6 | nM | Ki | Blood (2002) 100: 585-93 [PMID:12091352] |
| ChEMBL | Inhibition of Vascular endothelial growth factor receptor 2 | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
