blarcamesine [Ligand Id: 11586] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4297224 (Anavex, Anavex 2-73, Blarcamesine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| ChEMBL | Binding affinity to muscarinic acetylcholine receptor M1 (unknown origin) | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| ChEMBL | Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin) | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| ChEMBL | Binding affinity to muscarinic acetylcholine receptor M3 (unknown origin) | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
| M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| ChEMBL | Binding affinity to muscarinic acetylcholine receptor M4 (unknown origin) | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | Binding affinity to sigma-1 receptor (unknown origin) | B | 6.07 | pIC50 | 860 | nM | IC50 | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
| GtoPdb | - | - | 6.07 | pIC50 | 860 | nM | IC50 | J Psychopharmacol (2011) 25: 1101-17 [PMID:20829307] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
