ChEMBL ligand: CHEMBL6367 (GPI-1046)
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] FKBP prolyl isomerase 1A/FK506-binding protein 1A in Rat [ChEMBL: CHEMBL2095] [GtoPdb: 2609] [UniProtKB: Q62658] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 4/FK506 binding protein 4 in Human [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451] There should be some charts here, you may need to enable JavaScript!
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 8 in Human [GtoPdb: 3177] [UniProtKB: Q14318] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942]
ChEMBL	Binding affinity to FKBP12 (unknown origin)	B	6.51	pKi	306	nM	Ki	J Med Chem (2016) 59: 9622-9644 [PMID:27409354]
ChEMBL	Inhibitory activity against FK506 binding protein 12	B	8.12	pKi	7.5	nM	Ki	J Med Chem (2002) 45: 3549-3557 [PMID:12139466]
ChEMBL	The compound was tested for binding affinity against rotamase	B	8.12	pKi	7.5	nM	Ki	J Med Chem (1998) 41: 3928-3939 [PMID:9767630]
ChEMBL	Binding affinity to FKBP12 (unknown origin)	B	8.12	pKi	7.5	nM	Ki	J Med Chem (2016) 59: 9622-9644 [PMID:27409354]
ChEMBL	Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12	B	11	pKi	0.01	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1429-1433 [PMID:11992791]
ChEMBL	Binding affinity to FKBP12 by fluorescence polarization assay	B	5.91	pIC50	1240	nM	IC50	J Med Chem (2012) 55: 4114-4122 [PMID:22455444]
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2095] [GtoPdb: 2609] [UniProtKB: Q62658]
ChEMBL	In vitro inhibition of rotamase activity of FK506 binding protein 12	B	8.12	pKi	7.5	nM	Ki	J Med Chem (2002) 45: 3558-3568 [PMID:12139467]
FKBP prolyl isomerase 4/FK506 binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790]
ChEMBL	Binding affinity to FKBP52 (unknown origin)	B	6.03	pKi	936	nM	Ki	J Med Chem (2016) 59: 9622-9644 [PMID:27409354]
ChEMBL	Binding affinity to FKBP52 FK1 domain by fluorescence polarization assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2012) 55: 4114-4122 [PMID:22455444]
FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451]
ChEMBL	Binding affinity to FKBP51 (unknown origin)	B	6.35	pKi	447	nM	Ki	J Med Chem (2016) 59: 9622-9644 [PMID:27409354]
ChEMBL	Binding affinity to FKBP51 FK1 domain by fluorescence polarization assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2012) 55: 4114-4122 [PMID:22455444]
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
ChEMBL	The inhibitory activity by using FK506 binding protein 12 SPA binding assay	B	4.68	pIC50	20892.96	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1007-1010 [PMID:10843203]
FKBP prolyl isomerase 8 in Human [GtoPdb: 3177] [UniProtKB: Q14318]
GtoPdb	-	-	7.32	pKi	48	nM	Ki	J Biol Chem (2006) 281: 14961-70 [PMID:16547004]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]