SLF [Ligand Id: 11480] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL321022 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] | ||||||||
| ChEMBL | Binding affinity to FKBP12 by fluorescence polarization assay | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| GtoPdb | Binding affinity determined by a fluorescence polarization assay | - | 6.94 | pIC50 | 114 | nM | IC50 | J Med Chem (2012) 55: 4123-31 [PMID:22455398] |
| ChEMBL | Binding affinity to FKBP12 by competitive fluorescence polarization assay | B | 6.94 | pIC50 | 114 | nM | IC50 | J Med Chem (2012) 55: 4123-4131 [PMID:22455398] |
| ChEMBL | Inhibition of binding to Phe36Val (F36V) mutant of FK506 binding protein 12 | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3181-3184 [PMID:12951089] |
| FKBP prolyl isomerase 4/FK506 binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] | ||||||||
| ChEMBL | Binding affinity to FKBP52 FK1 domain by fluorescence polarization assay | B | 4.98 | pIC50 | 10500 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| ChEMBL | Binding affinity to FKBP52 FK1 domain by competitive fluorescence polarization assay | B | 5.03 | pIC50 | 9370 | nM | IC50 | J Med Chem (2012) 55: 4123-4131 [PMID:22455398] |
| GtoPdb | Binding affinity determined by a fluorescence polarization assay | - | 5.03 | pIC50 | 9370 | nM | IC50 | J Med Chem (2012) 55: 4123-31 [PMID:22455398] |
| FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451] | ||||||||
| ChEMBL | Binding affinity to FKBP51 FK1 domain by fluorescence polarization assay | B | 5.08 | pIC50 | 8360 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| GtoPdb | Binding affinity determined by a fluorescence polarization assay | - | 5.2 | pIC50 | 6300 | nM | IC50 | J Med Chem (2012) 55: 4123-31 [PMID:22455398] |
| ChEMBL | Binding affinity to FKBP51 FK1 domain by competitive fluorescence polarization assay | B | 5.2 | pIC50 | 6300 | nM | IC50 | J Med Chem (2012) 55: 4123-4131 [PMID:22455398] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
