isobutyric acid [Ligand Id: 1060] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL108778 (Isobutyric Acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FFA3 receptor in Human [GtoPdb: 227] [UniProtKB: O14843] | ||||||||
| GtoPdb | - | - | 4.8 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11312-9 [PMID:12496283]; Proc Natl Acad Sci USA (2004) 101: 1045-50 [PMID:14722361] |
| FFA3 receptor/Free fatty acid receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886125] [GtoPdb: 227] [UniProtKB: B2GV46] | ||||||||
| ChEMBL | Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay | B | 4.52 | pEC50 | 30000 | nM | EC50 | WO-2001061359-A2. Identification of modulators of GPR41 or GPR42 activity (2001) |
| FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552] | ||||||||
| GtoPdb | - | - | 3.8 | pEC50 | - | - | - | J Biol Chem (2003) 278: 25481-9 [PMID:12711604] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
