ChEMBL ligand: CHEMBL8659 (18:1(N-9), 9-octadecenoic acid, (z)-, 9z-octadecenoic acid, FEMA NO. 2815, NSC-9856, Oleate, Oleic acid, Osteum, Priolene 6936, Vopcolene 27, Wecoline oo)
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] There should be some charts here, you may need to enable JavaScript!
coagulation factor VII/coagulation factor III, tissue factor/Coagulation factor VII/tissue factor in Human [ChEMBL: CHEMBL2095194] [GtoPdb: 2363, 3192] [UniProtKB: P08709, P13726] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
DNA topoisomerase I in Human [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387] There should be some charts here, you may need to enable JavaScript!
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090] There should be some charts here, you may need to enable JavaScript!
fatty acid binding protein 5/Fatty acid binding protein epidermal in Human [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469] There should be some charts here, you may need to enable JavaScript!
fatty acid binding protein 1/Fatty acid-binding protein, liver in Human [ChEMBL: CHEMBL5421] [GtoPdb: 2531] [UniProtKB: P07148] fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692] There should be some charts here, you may need to enable JavaScript!
sirtuin 6/NAD-dependent protein deacetylase sirtuin-6 in Human [ChEMBL: CHEMBL2163182] [GtoPdb: 2712] [UniProtKB: Q8N6T7] There should be some charts here, you may need to enable JavaScript!
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
Seed lipoxygenase-1 in Glycine max [ChEMBL: CHEMBL4586] [UniProtKB: P08170] There should be some charts here, you may need to enable JavaScript!
Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746] There should be some charts here, you may need to enable JavaScript!
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] There should be some charts here, you may need to enable JavaScript!
FFA4 receptor in Human [GtoPdb: 127] [UniProtKB: Q5NUL3] There should be some charts here, you may need to enable JavaScript!
FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL	Inhibition of FAAH	B	5.22	pKi	6000	nM	Ki	J Med Chem (2008) 51: 7327-7343 [PMID:18983142]
coagulation factor VII/coagulation factor III, tissue factor/Coagulation factor VII/tissue factor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095194] [GtoPdb: 2363, 3192] [UniProtKB: P08709, P13726]
ChEMBL	Inhibition of amidolytic activity of human tissue factor/human factor 7a	B	4.1	pIC50	80000	nM	IC50	J Nat Prod (1998) 61: 1352-1355 [PMID:9834151]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Inhibition of aromatase in human placental microsomes by radiometric method	B	4.49	pIC50	32700	nM	IC50	J Nat Prod (2006) 69: 700-703 [PMID:16643058]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL	Inhibition of DNA topoisomerase 1	B	4.51	pIC50	31000	nM	IC50	J Nat Prod (2002) 65: 1715-1718 [PMID:12444712]
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090]
ChEMBL	Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay	B	5.82	pKi	1500	nM	Ki	Bioorg Med Chem (2016) 24: 4310-4317 [PMID:27460668]
ChEMBL	Displacement of 1,8-ANS from aFABP by fluorescence based-assay	B	6.73	pKi	185	nM	Ki	Bioorg Med Chem Lett (2007) 17: 3511-3515 [PMID:17502136]
ChEMBL	Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins	B	4.58	pIC50	26100	nM	IC50	Bioorg Med Chem Lett (2010) 20: 3675-3679 [PMID:20471252]
fatty acid binding protein 5/Fatty acid binding protein epidermal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469]
ChEMBL	Displacement of 1,8-ANS from eFABP by fluorescence based-assay	B	6.61	pKi	248	nM	Ki	Bioorg Med Chem Lett (2007) 17: 3511-3515 [PMID:17502136]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5421] [GtoPdb: 2531] [UniProtKB: P07148]
ChEMBL	Binding affinity to L-FABP low binding affinity site by titration calorimetry method	B	6.05	pKd	900	nM	Kd	J Med Chem (2008) 51: 3755-3764 [PMID:18533710]
ChEMBL	Binding affinity to L-FABP high binding affinity site by titration calorimetry method	B	6.7	pKd	200	nM	Kd	J Med Chem (2008) 51: 3755-3764 [PMID:18533710]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
ChEMBL	Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay	B	5.54	pKi	2900	nM	Ki	J Med Chem (2008) 51: 3755-3764 [PMID:18533710]
ChEMBL	Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay	B	6.74	pKi	180	nM	Ki	J Med Chem (2008) 51: 3755-3764 [PMID:18533710]
sirtuin 6/NAD-dependent protein deacetylase sirtuin-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163182] [GtoPdb: 2712] [UniProtKB: Q8N6T7]
ChEMBL	Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrate	B	4.05	pEC50	90000	nM	EC50	J Med Chem (2021) 64: 9732-9758 [PMID:34213345]
ChEMBL	Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrate	B	4.05	pEC50	89000	nM	EC50	J Med Chem (2021) 64: 9732-9758 [PMID:34213345]
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354]
ChEMBL	Binding affinity towards Nurr1 ligand binding domain (unknown origin) measured by tryptophan fluorescence spectroscopy	B	4.3	pKd	50000	nM	Kd	J Med Chem (2022) 65: 9548-9563 [PMID:35797147]
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL	Inhibition of PPAR-alpha (unknown origin) by SPA assay	B	6.22	pIC50	600	nM	IC50	Med Chem Res (2009) 18: 8-19
ChEMBL	Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay	B	6.22	pIC50	600	nM	IC50	Med Chem Res (2013) 22: 3126-3133
ChEMBL	Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay	B	4.44	pEC50	36000	nM	EC50	J Med Chem (2022) 65: 1961-1978 [PMID:35089724]
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
ChEMBL	Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay	B	5.28	pIC50	5300	nM	IC50	Med Chem Res (2013) 22: 3126-3133
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay	B	5.39	pIC50	4100	nM	IC50	Med Chem Res (2013) 22: 3126-3133
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by photometric method	B	5.21	pIC50	6200	nM	IC50	J Nat Prod (2020) 83: 1598-1610 [PMID:32255628]
Seed lipoxygenase-1 in Glycine max (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4586] [UniProtKB: P08170]
ChEMBL	Binding affinity to soybean LO1	B	4.66	pKi	22000	nM	Ki	Bioorg Med Chem (2009) 17: 6534-6539 [PMID:19716306]
Telomerase reverse transcriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
ChEMBL	Inhibition of telomerase extracted from human K562 cells preincubated for 10 mins followed by dNTPs and telomerase substrate primer TS-A addition measured after 30 mins by TRAP assay	B	5.07	pIC50	8600	nM	IC50	Medchemcomm (2011) 2: 229-245
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
ChEMBL	Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry	B	5	pIC50	>10000	nM	IC50	J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
ChEMBL	Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry	B	5	pIC50	>10000	nM	IC50	J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
FFA4 receptor in Human [GtoPdb: 127] [UniProtKB: Q5NUL3]
GtoPdb	-	-	4.7	pEC50	-	-	-	Mol Pharmacol (2012) 81: 631-42 [PMID:22282525]
FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842]
GtoPdb	-	-	5.7	pEC50	-	-	-	J Biol Chem (2003) 278: 11303-11 [PMID:12496284]; Biochem Biophys Res Commun (2003) 301: 406-10 [PMID:12565875]; Nature (2003) 422: 173-6 [PMID:12629551]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]