oleic acid [Ligand Id: 1054] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL8659 (18:1(N-9), 9-octadecenoic acid, (z)-, 9z-octadecenoic acid, FEMA NO. 2815, NSC-9856, Oleate, Oleic acid, Osteum, Priolene 6936, Vopcolene 27, Wecoline oo) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of FAAH | B | 5.22 | pKi | 6000 | nM | Ki | J Med Chem (2008) 51: 7327-7343 [PMID:18983142] |
| coagulation factor VII/coagulation factor III, tissue factor/Coagulation factor VII/tissue factor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095194] [GtoPdb: 2363, 3192] [UniProtKB: P08709, P13726] | ||||||||
| ChEMBL | Inhibition of amidolytic activity of human tissue factor/human factor 7a | B | 4.1 | pIC50 | 80000 | nM | IC50 | J Nat Prod (1998) 61: 1352-1355 [PMID:9834151] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of aromatase in human placental microsomes by radiometric method | B | 4.49 | pIC50 | 32700 | nM | IC50 | J Nat Prod (2006) 69: 700-703 [PMID:16643058] |
| DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387] | ||||||||
| ChEMBL | Inhibition of DNA topoisomerase 1 | B | 4.51 | pIC50 | 31000 | nM | IC50 | J Nat Prod (2002) 65: 1715-1718 [PMID:12444712] |
| fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090] | ||||||||
| ChEMBL | Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay | B | 5.82 | pKi | 1500 | nM | Ki | Bioorg Med Chem (2016) 24: 4310-4317 [PMID:27460668] |
| ChEMBL | Displacement of 1,8-ANS from aFABP by fluorescence based-assay | B | 6.73 | pKi | 185 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3511-3515 [PMID:17502136] |
| ChEMBL | Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins | B | 4.58 | pIC50 | 26100 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 3675-3679 [PMID:20471252] |
| fatty acid binding protein 5/Fatty acid binding protein epidermal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469] | ||||||||
| ChEMBL | Displacement of 1,8-ANS from eFABP by fluorescence based-assay | B | 6.61 | pKi | 248 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3511-3515 [PMID:17502136] |
| fatty acid binding protein 1/Fatty acid-binding protein, liver in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5421] [GtoPdb: 2531] [UniProtKB: P07148] | ||||||||
| ChEMBL | Binding affinity to L-FABP low binding affinity site by titration calorimetry method | B | 6.05 | pKd | 900 | nM | Kd | J Med Chem (2008) 51: 3755-3764 [PMID:18533710] |
| ChEMBL | Binding affinity to L-FABP high binding affinity site by titration calorimetry method | B | 6.7 | pKd | 200 | nM | Kd | J Med Chem (2008) 51: 3755-3764 [PMID:18533710] |
| fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692] | ||||||||
| ChEMBL | Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay | B | 5.54 | pKi | 2900 | nM | Ki | J Med Chem (2008) 51: 3755-3764 [PMID:18533710] |
| ChEMBL | Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay | B | 6.74 | pKi | 180 | nM | Ki | J Med Chem (2008) 51: 3755-3764 [PMID:18533710] |
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Inhibition of PPAR-alpha (unknown origin) by SPA assay | B | 6.22 | pIC50 | 600 | nM | IC50 | Med Chem Res (2009) 18: 8-19 |
| ChEMBL | Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay | B | 6.22 | pIC50 | 600 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
| ChEMBL | Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay | B | 5.28 | pIC50 | 5300 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay | B | 5.39 | pIC50 | 4100 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by photometric method | B | 5.21 | pIC50 | 6200 | nM | IC50 | J Nat Prod (2020) 83: 1598-1610 [PMID:32255628] |
| Seed lipoxygenase-1 in Glycine max (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4586] [UniProtKB: P08170] | ||||||||
| ChEMBL | Binding affinity to soybean LO1 | B | 4.66 | pKi | 22000 | nM | Ki | Bioorg Med Chem (2009) 17: 6534-6539 [PMID:19716306] |
| Telomerase reverse transcriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2916] [UniProtKB: O14746] | ||||||||
| ChEMBL | Inhibition of telomerase extracted from human K562 cells preincubated for 10 mins followed by dNTPs and telomerase substrate primer TS-A addition measured after 30 mins by TRAP assay | B | 5.07 | pIC50 | 8600 | nM | IC50 | Medchemcomm (2011) 2: 229-245 |
| TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] | ||||||||
| ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
| ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
| FFA4 receptor in Human [GtoPdb: 127] [UniProtKB: Q5NUL3] | ||||||||
| GtoPdb | - | - | 4.7 | pEC50 | - | - | - | Mol Pharmacol (2012) 81: 631-42 [PMID:22282525] |
| FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842] | ||||||||
| GtoPdb | - | - | 5.7 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11303-11 [PMID:12496284]; Biochem Biophys Res Commun (2003) 301: 406-10 [PMID:12565875]; Nature (2003) 422: 173-6 [PMID:12629551] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
