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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 132 | 8q21.13 | FABP4 | fatty acid binding protein 4 | |
Mouse | - | 132 | 3 2.56 cM | Fabp4 | fatty acid binding protein 4, adipocyte | |
Rat | - | 132 | 2q23 | Fabp4 | fatty acid binding protein 4 |
Previous and Unofficial Names |
adipocyte lipid-binding protein | adipocyte protein aP2 | AFABP | ALBP |
Database Links | |
Alphafold | P15090 (Hs), P04117 (Mm), P70623 (Rn) |
CATH/Gene3D | 2.40.128.20 |
ChEMBL Target | CHEMBL2083 (Hs), CHEMBL1075118 (Mm), CHEMBL2021755 (Rn) |
Ensembl Gene | ENSG00000170323 (Hs), ENSMUSG00000062515 (Mm), ENSRNOG00000010805 (Rn) |
Entrez Gene | 2167 (Hs), 11770 (Mm), 79451 (Rn) |
Human Protein Atlas | ENSG00000170323 (Hs) |
KEGG Gene | hsa:2167 (Hs), mmu:11770 (Mm), rno:79451 (Rn) |
OMIM | 600434 (Hs) |
Pharos | P15090 (Hs) |
RefSeq Nucleotide | NM_001442 (Hs), NM_024406 (Mm) |
RefSeq Protein | NP_001433 (Hs), NP_077717 (Mm) |
SynPHARM | 82981 (in complex with HTS01037) |
UniProtKB | P15090 (Hs), P04117 (Mm), P70623 (Rn) |
Wikipedia | FABP4 (Hs) |
Selected 3D Structures | |||||||||||||
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Rank order of potency (Human) |
oleic acid, palmitic acid, stearic acid, linoleic acid > α-linolenic acid, arachidonic acid [4] |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific inhibitor tables |
Immuno Process Associations | ||
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1. Hertzel AV, Hellberg K, Reynolds JM, Kruse AC, Juhlmann BE, Smith AJ, Sanders MA, Ohlendorf DH, Suttles J, Bernlohr DA. (2009) Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. J Med Chem, 52 (19): 6024-31. [PMID:19754198]
2. Liu X, Huang X, Lin W, Wang D, Diao Y, Li H, Hui X, Wang Y, Xu A, Wu D et al.. (2011) New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg Med Chem Lett, 21 (10): 2949-52. [PMID:21481589]
3. Oddi S, Scipioni L, Totaro A, Angelucci C, Dufrusine B, Sabatucci A, Tortolani D, Coletta I, Alisi MA, Polenzani L et al.. (2019) The anti-inflammatory agent bindarit acts as a modulator of fatty acid-binding protein 4 in human monocytic cells. Sci Rep, 9 (1): 15155. [PMID:31641194]
4. Richieri GV, Ogata RT, Kleinfeld AM. (1994) Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J Biol Chem, 269 (39): 23918-30. [PMID:7929039]
5. Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R et al.. (2007) Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett, 17 (12): 3511-5. [PMID:17502136]
Fatty acid-binding proteins: fatty acid binding protein 4. Last modified on 18/07/2020. Accessed on 03/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2534.