CWHM12 [Ligand Id: 10495] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3319237
  • integrin, alpha 10 subunit/integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/Integrin alpha-10/Integrin beta-1 in Human [ChEMBL: CHEMBL3430895] [GtoPdb: 2438, 2455] [UniProtKB: O75578, P05556]
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  • integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 2 subunit (CD49B, alpha 2 subunit of VLA-2 receptor)/Integrin alpha2/beta1 in Human [ChEMBL: CHEMBL3137268] [GtoPdb: 2455, 2440] [UniProtKB: P05556, P17301]
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  • integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514]
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  • integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha V subunit/Integrin alpha-V/beta-1 in Human [ChEMBL: CHEMBL2111407] [GtoPdb: 2455, 2453] [UniProtKB: P05556, P06756]
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  • integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human [ChEMBL: CHEMBL1907598] [GtoPdb: 2457, 2453] [UniProtKB: P05106, P06756]
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  • integrin αVβ3 in Human [GtoPdb: 2583]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
integrin, alpha 10 subunit/integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/Integrin alpha-10/Integrin beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430895] [GtoPdb: 2438, 2455] [UniProtKB: O75578, P05556]
ChEMBL Antagonist activity at alpha10beta1 integrin receptor (unknown origin) by cell-free ELISA B 5.3 pIC50 >5000 nM IC50 J Med Chem (2014) 57: 6301-6315 [PMID:24568695]
integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 2 subunit (CD49B, alpha 2 subunit of VLA-2 receptor)/Integrin alpha2/beta1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3137268] [GtoPdb: 2455, 2440] [UniProtKB: P05556, P17301]
ChEMBL Antagonist activity at alpha2beta1 integrin receptor (unknown origin) by cell-free ELISA B 5.3 pIC50 >5000 nM IC50 J Med Chem (2014) 57: 6301-6315 [PMID:24568695]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514]
ChEMBL Antagonist activity at alpha2bbeta3 integrin receptor (unknown origin) by cell-free ELISA B 5.3 pIC50 >5000 nM IC50 J Med Chem (2014) 57: 6301-6315 [PMID:24568695]
integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha V subunit/Integrin alpha-V/beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111407] [GtoPdb: 2455, 2453] [UniProtKB: P05556, P06756]
ChEMBL Antagonist activity at alphavbeta1 integrin receptor (unknown origin) by cell-free ELISA B 8.74 pIC50 1.8 nM IC50 J Med Chem (2014) 57: 6301-6315 [PMID:24568695]
ChEMBL Inhibition of human fibronectin binding to human integrin alphavbeta1 after 2 hrs B 8.74 pIC50 1.8 nM IC50 J Med Chem (2019) 62: 7543-7556 [PMID:31381331]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907598] [GtoPdb: 2457, 2453] [UniProtKB: P05106, P06756]
ChEMBL Antagonist activity at alphavbeta3 integrin receptor (unknown origin) by cell-based ELISA B 9.1 pIC50 0.8 nM IC50 J Med Chem (2014) 57: 6301-6315 [PMID:24568695]
ChEMBL Inhibition of integrin alphavbeta3 (unknown origin) by radioligand binding assay B 9.1 pIC50 0.8 nM IC50 J Med Chem (2019) 62: 7543-7556 [PMID:31381331]
integrin, alpha V subunit/integrin, beta 5 subunit/Integrin alpha-V/beta-5 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096675] [GtoPdb: 2453, 2459] [UniProtKB: P06756, P18084]
ChEMBL Antagonist activity at alphavbeta5 integrin receptor (unknown origin) by cell-based ELISA B 7.21 pIC50 61 nM IC50 J Med Chem (2014) 57: 6301-6315 [PMID:24568695]
ChEMBL Inhibition of integrin alphavbeta5 (unknown origin) by radioligand binding assay B 7.21 pIC50 61 nM IC50 J Med Chem (2019) 62: 7543-7556 [PMID:31381331]
integrin, alpha V subunit/integrin, beta 6 subunit/Integrin alpha-V/beta-6 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111416] [GtoPdb: 2453, 2460] [UniProtKB: P06756, P18564]
ChEMBL Antagonist activity at alphavbeta6 integrin receptor (unknown origin) by cell-based ELISA B 8.82 pIC50 1.5 nM IC50 J Med Chem (2014) 57: 6301-6315 [PMID:24568695]
ChEMBL Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assay B 8.82 pIC50 1.5 nM IC50 J Med Chem (2019) 62: 7543-7556 [PMID:31381331]
integrin, alpha V subunit/integrin, beta 8 subunit/Integrin alpha-V/beta-8 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430892] [GtoPdb: 2453, 2462] [UniProtKB: P06756, P26012]
ChEMBL Antagonist activity at alphavbeta8 integrin receptor (unknown origin) by cell-free ELISA B 9.7 pIC50 0.2 nM IC50 J Med Chem (2014) 57: 6301-6315 [PMID:24568695]
integrin αVβ3 in Human [GtoPdb: 2583]
GtoPdb IC50 determined in an in vitro ligand-binding assay. - 9.1 pIC50 0.8 nM IC50 Nat Med (2013) 19: 1617-24 [PMID:24216753]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]