CWHM12 [Ligand Id: 10495] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL3319237
  • integrin, alpha 10 subunit/integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/Integrin alpha-10/Integrin beta-1 in Human [ChEMBL: CHEMBL3430895] [GtoPdb: 24382455] [UniProtKB: O75578P05556]
There should be some charts here, you may need to enable JavaScript!
  • integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 2 subunit (CD49B, alpha 2 subunit of VLA-2 receptor)/Integrin alpha2/beta1 in Human [ChEMBL: CHEMBL3137268] [GtoPdb: 24552440] [UniProtKB: P05556P17301]
There should be some charts here, you may need to enable JavaScript!
  • integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human [ChEMBL: CHEMBL2093869] [GtoPdb: 24572441] [UniProtKB: P05106P08514]
There should be some charts here, you may need to enable JavaScript!
  • integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha V subunit/Integrin alpha-V/beta-1 in Human [ChEMBL: CHEMBL2111407] [GtoPdb: 24552453] [UniProtKB: P05556P06756]
There should be some charts here, you may need to enable JavaScript!
  • integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human [ChEMBL: CHEMBL1907598] [GtoPdb: 24572453] [UniProtKB: P05106P06756]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • integrin αVβ3 in Human [GtoPdb: 2583]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
integrin, alpha 10 subunit/integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/Integrin alpha-10/Integrin beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430895] [GtoPdb: 24382455] [UniProtKB: O75578P05556]
ChEMBL Antagonist activity at alpha10beta1 integrin receptor (unknown origin) by cell-free ELISA B 5.3 pIC50 >5000 nM IC50 J. Med. Chem. (2014) 57: 6301-6315 [PMID:24568695]
integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 2 subunit (CD49B, alpha 2 subunit of VLA-2 receptor)/Integrin alpha2/beta1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3137268] [GtoPdb: 24552440] [UniProtKB: P05556P17301]
ChEMBL Antagonist activity at alpha2beta1 integrin receptor (unknown origin) by cell-free ELISA B 5.3 pIC50 >5000 nM IC50 J. Med. Chem. (2014) 57: 6301-6315 [PMID:24568695]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 24572441] [UniProtKB: P05106P08514]
ChEMBL Antagonist activity at alpha2bbeta3 integrin receptor (unknown origin) by cell-free ELISA B 5.3 pIC50 >5000 nM IC50 J. Med. Chem. (2014) 57: 6301-6315 [PMID:24568695]
integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha V subunit/Integrin alpha-V/beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111407] [GtoPdb: 24552453] [UniProtKB: P05556P06756]
ChEMBL Antagonist activity at alphavbeta1 integrin receptor (unknown origin) by cell-free ELISA B 8.74 pIC50 1.8 nM IC50 J. Med. Chem. (2014) 57: 6301-6315 [PMID:24568695]
ChEMBL Inhibition of human fibronectin binding to human integrin alphavbeta1 after 2 hrs B 8.74 pIC50 1.8 nM IC50 J Med Chem (2019) 62: 7543-7556 [PMID:31381331]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907598] [GtoPdb: 24572453] [UniProtKB: P05106P06756]
ChEMBL Antagonist activity at alphavbeta3 integrin receptor (unknown origin) by cell-based ELISA B 9.1 pIC50 0.8 nM IC50 J. Med. Chem. (2014) 57: 6301-6315 [PMID:24568695]
ChEMBL Inhibition of integrin alphavbeta3 (unknown origin) by radioligand binding assay B 9.1 pIC50 0.8 nM IC50 J Med Chem (2019) 62: 7543-7556 [PMID:31381331]
integrin, alpha V subunit/integrin, beta 5 subunit/Integrin alpha-V/beta-5 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096675] [GtoPdb: 24532459] [UniProtKB: P06756P18084]
ChEMBL Antagonist activity at alphavbeta5 integrin receptor (unknown origin) by cell-based ELISA B 7.21 pIC50 61 nM IC50 J. Med. Chem. (2014) 57: 6301-6315 [PMID:24568695]
ChEMBL Inhibition of integrin alphavbeta5 (unknown origin) by radioligand binding assay B 7.21 pIC50 61 nM IC50 J Med Chem (2019) 62: 7543-7556 [PMID:31381331]
integrin, alpha V subunit/integrin, beta 6 subunit/Integrin alpha-V/beta-6 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111416] [GtoPdb: 24532460] [UniProtKB: P06756P18564]
ChEMBL Antagonist activity at alphavbeta6 integrin receptor (unknown origin) by cell-based ELISA B 8.82 pIC50 1.5 nM IC50 J. Med. Chem. (2014) 57: 6301-6315 [PMID:24568695]
ChEMBL Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assay B 8.82 pIC50 1.5 nM IC50 J Med Chem (2019) 62: 7543-7556 [PMID:31381331]
integrin, alpha V subunit/integrin, beta 8 subunit/Integrin alpha-V/beta-8 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430892] [GtoPdb: 24532462] [UniProtKB: P06756P26012]
ChEMBL Antagonist activity at alphavbeta8 integrin receptor (unknown origin) by cell-free ELISA B 9.7 pIC50 0.2 nM IC50 J. Med. Chem. (2014) 57: 6301-6315 [PMID:24568695]
integrin αVβ3 in Human [GtoPdb: 2583]
GtoPdb IC50 determined in an in vitro ligand-binding assay. - 9.1 pIC50 0.8 nM IC50 Nat Med (2013) 19: 1617-24 [PMID:24216753]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]