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integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

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Target not currently curated in GtoImmuPdb

Target id: 2455

Nomenclature: integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

Family: Integrins

Contents:

Quaternary Structure: Complexes
integrin α1β1
integrin α2β1
integrin α4β1
integrin α5β1
integrin α6β1
integrin α10β1
integrin α11β1
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 798 10p11.22 ITGB1 integrin subunit beta 1
Mouse 1 798 8 E2 Itgb1 integrin beta 1 (fibronectin receptor beta)
Rat 1 799 19q12 Itgb1 integrin subunit beta 1
Previous and Unofficial Names Click here for help
MDF2 | MSK12 | Glycoprotein IIa | GPIIA | beta1 integrin | CD antigen CD29 | Fibronectin receptor subunit beta | FNRB | VLA-4 subunit beta | integrin, beta 1
Database Links Click here for help
Alphafold P05556 (Hs), P09055 (Mm), P49134 (Rn)
CATH/Gene3D 1.20.5.630
ChEMBL Target CHEMBL1905 (Hs)
DrugBank Target P05556 (Hs)
Ensembl Gene ENSG00000150093 (Hs), ENSMUSG00000025809 (Mm), ENSRNOG00000010966 (Rn)
Entrez Gene 3688 (Hs), 16412 (Mm), 24511 (Rn)
Human Protein Atlas ENSG00000150093 (Hs)
KEGG Gene hsa:3688 (Hs), mmu:16412 (Mm), rno:24511 (Rn)
OMIM 135630 (Hs)
Pharos P05556 (Hs)
RefSeq Nucleotide NM_133376 (Hs), NM_033668 (Hs), NM_002211 (Hs), XM_134403 (Mm), NM_017022 (Rn)
RefSeq Protein NP_002202 (Hs), NP_391988 (Hs), NP_596867 (Hs), NP_034708 (Mm), NP_058718 (Rn)
UniProtKB P05556 (Hs), P09055 (Mm), P49134 (Rn)
Wikipedia ITGB1 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 7 [PMID: 31381331] Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 7.7 pKi 1
⤷ pKi 7.7 (Ki 2x10-8 M) [1]
Description: Ki estimated from the binding affinity of the test compound to αvβ6 integrin in a radioligand binding assay.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0006909 phagocytosis ISS
GO:0050901 leukocyte tethering or rolling IMP
GO:0150103 reactive gliosis ISS
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0031623 receptor internalization ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0007159 leukocyte cell-cell adhesion IDA
GO:0050901 leukocyte tethering or rolling IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001618 virus receptor activity IEA

References

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1. Barrett TN, Taylor JA, Barker D, Procopiou PA, Thompson JDF, Barrett J, Le J, Lynn SM, Pogany P, Pratley C et al.. (2019) Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation. J Med Chem, 62 (16): 7543-7556. [PMID:31381331]

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