Quaternary Structure: Complexes

integrin α1β1

integrin α2β1

integrin α4β1

integrin α5β1

integrin α6β1

integrin α10β1

integrin α11β1

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	798	10p11.22	ITGB1	integrin subunit beta 1
Mouse	1	798	8 E2	Itgb1	integrin beta 1 (fibronectin receptor beta)
Rat	1	799	19q12	Itgb1	integrin subunit beta 1

Previous and Unofficial Names

beta1 integrin | CD antigen CD29 | Fibronectin receptor subunit beta | FNRB | Glycoprotein IIa | GPIIA | MDF2 | MSK12 | VLA-4 subunit beta | integrin, beta 1

Database Links
Alphafold	P05556 (Hs), P09055 (Mm), P49134 (Rn)
CATH/Gene3D	1.20.5.630
ChEMBL Target	CHEMBL1905 (Hs)
DrugBank Target	P05556 (Hs)
Ensembl Gene	ENSG00000150093 (Hs), ENSMUSG00000025809 (Mm), ENSRNOG00000010966 (Rn)
Entrez Gene	3688 (Hs), 16412 (Mm), 24511 (Rn)
Human Protein Atlas	ENSG00000150093 (Hs)
KEGG Gene	hsa:3688 (Hs), mmu:16412 (Mm), rno:24511 (Rn)
OMIM	135630 (Hs)
Pharos	P05556 (Hs)
RefSeq Nucleotide	NM_133376 (Hs), NM_033668 (Hs), NM_002211 (Hs), XM_134403 (Mm), NM_017022 (Rn)
RefSeq Protein	NP_596867 (Hs), NP_391988 (Hs), NP_002202 (Hs), NP_034708 (Mm), NP_058718 (Rn)
UniProtKB	P05556 (Hs), P09055 (Mm), P49134 (Rn)
Wikipedia	ITGB1 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 7 [PMID: 31381331] Hs Inhibition 7.7 pKi 1 ⤷ pKi 7.7 (Ki 2x10-8 M) [1] Description: Ki estimated from the binding affinity of the test compound to αvβ6 integrin in a radioligand binding assay.

Immuno Process Associations

Immuno Process:  Antigen presentation GO Annotations:  Associated to 2 GO processes GO:0006909 phagocytosis ISS GO:0031623 receptor internalization ISS

Immuno Process:  Barrier integrity GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0001618 virus receptor activity IEA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes GO:0030183 B cell differentiation IC

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0030183 B cell differentiation IC

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 2 GO processes GO:0007159 leukocyte cell-cell adhesion IDA GO:0050901 leukocyte tethering or rolling IMP

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0030183 B cell differentiation IC

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes GO:0006909 phagocytosis ISS GO:0050901 leukocyte tethering or rolling IMP GO:0150103 reactive gliosis ISS