compound 20 [PMID: 30998356] [Ligand Id: 10371] activity data from GtoPdb

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  • mitogen-activated protein kinase 8 in Human [GtoPdb: 1496] [UniProtKB: P45983]
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  • mitogen-activated protein kinase 9 in Human [GtoPdb: 1497] [UniProtKB: P45984]
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  • mitogen-activated protein kinase 10 in Human [GtoPdb: 1498] [UniProtKB: P53779]
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  • leukocyte receptor tyrosine kinase in Human [GtoPdb: 1838] [UniProtKB: P29376]
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  • CDC like kinase 2 in Human [GtoPdb: 1991] [UniProtKB: P49760]
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  • dual specificity tyrosine phosphorylation regulated kinase 3 in Human [GtoPdb: 2012] [UniProtKB: O43781]
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  • leucine rich repeat kinase 2 in Human [GtoPdb: 2059] [UniProtKB: Q5S007]
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  • testis specific serine kinase 1B in Human [GtoPdb: 2257] [UniProtKB: Q9BXA7]
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  • TTK protein kinase in Human [GtoPdb: 2264] [UniProtKB: P33981]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 8 in Human [GtoPdb: 1496] [UniProtKB: P45983]
GtoPdb Measuring in vitro enzyme inhibitory activity. - 7.49 pIC50 32 nM IC50 J Med Chem (2019) 62: 4401-4410 [PMID:30998356]
mitogen-activated protein kinase 9 in Human [GtoPdb: 1497] [UniProtKB: P45984]
GtoPdb Measuring in vitro enzyme inhibitory activity. - 7.23 pIC50 59 nM IC50 J Med Chem (2019) 62: 4401-4410 [PMID:30998356]
mitogen-activated protein kinase 10 in Human [GtoPdb: 1498] [UniProtKB: P53779]
GtoPdb Measuring in vitro enzyme inhibitory activity. - 6.97 pIC50 107 nM IC50 J Med Chem (2019) 62: 4401-4410 [PMID:30998356]
leukocyte receptor tyrosine kinase in Human [GtoPdb: 1838] [UniProtKB: P29376]
GtoPdb Measuring in vitro enzyme inhibitory activity. - 6.25 pKi 567 nM Ki J Med Chem (2019) 62: 4401-4410 [PMID:30998356]
CDC like kinase 2 in Human [GtoPdb: 1991] [UniProtKB: P49760]
GtoPdb Measuring in vitro enzyme inhibitory activity. - 6.58 pIC50 261 nM IC50 J Med Chem (2019) 62: 4401-4410 [PMID:30998356]
dual specificity tyrosine phosphorylation regulated kinase 3 in Human [GtoPdb: 2012] [UniProtKB: O43781]
GtoPdb Measuring in vitro enzyme inhibitory activity. - 6.98 pIC50 104 nM IC50 J Med Chem (2019) 62: 4401-4410 [PMID:30998356]
leucine rich repeat kinase 2 in Human [GtoPdb: 2059] [UniProtKB: Q5S007]
GtoPdb Measuring in vitro enzyme inhibitory activity. - 9 pIC50 1 nM IC50 J Med Chem (2019) 62: 4401-4410 [PMID:30998356]
testis specific serine kinase 1B in Human [GtoPdb: 2257] [UniProtKB: Q9BXA7]
GtoPdb Measuring in vitro enzyme inhibitory activity. - 6.66 pIC50 217 nM IC50 J Med Chem (2019) 62: 4401-4410 [PMID:30998356]
TTK protein kinase in Human [GtoPdb: 2264] [UniProtKB: P33981]
GtoPdb In vitro inhibitory activity using the proprietary LanthaScreen Eu kinase binding assay. - 9.15 pIC50 0.7 nM IC50 J Med Chem (2019) 62: 4401-4410 [PMID:30998356]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.