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ChEMBL ligand: CHEMBL52229 (Osthole) |
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6
CHEMBL52229_lig_chart_6
TRPV3
Human
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] | ||||||||
ChEMBL | Inhibition of 5-lipoxygenase | B | 4.44 | pIC50 | 36200 | nM | IC50 | J. Nat. Prod. (1998) 61: 347-350 [PMID:9544564] |
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
ChEMBL | Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately | B | 4.28 | pIC50 | 52500 | nM | IC50 | J Nat Prod (2017) 80: 2472-2477 [PMID:28885836] |
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
ChEMBL | Inhibition of human COX2 expressed in insect cells using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately | B | 4.09 | pIC50 | 81100 | nM | IC50 | J Nat Prod (2017) 80: 2472-2477 [PMID:28885836] |
exportin 1/Exportin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5661] [GtoPdb: 3014] [UniProtKB: O14980] | ||||||||
ChEMBL | Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg. Med. Chem. Lett. (2010) 20: 3717-3720 [PMID:20493693] |
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
ChEMBL | Inhibition of P-gp in human LS180 cells after 90 mins by rhodamine123 cell exclusion method | B | 4.47 | pIC50 | 34000 | nM | IC50 | MedChemComm (2014) 5: 1540-1547 |
TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8] | ||||||||
GtoPdb | - | - | 4.4 | pIC50 | - | - | - | Mol. Pharmacol. (2018) 94: 1164-1173 [PMID:30108138] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]