ChEMBL ligand: CHEMBL52229 (Osthole)
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] This target only has 0 pki data point 1 CHEMBL52229_lig_chart_1 Arachidonate 5-lipoxygenase Human There should be some charts here, you may need to enable JavaScript!
Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] This target only has 0 pki data point 2 CHEMBL52229_lig_chart_2 Cyclooxygenase-1 Sheep There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] This target only has 0 pki data point 3 CHEMBL52229_lig_chart_3 Cyclooxygenase-2 Human There should be some charts here, you may need to enable JavaScript!
exportin 1/Exportin-1 in Human [ChEMBL: CHEMBL5661] [GtoPdb: 3014] [UniProtKB: O14980] This target only has 0 pki data point 4 CHEMBL52229_lig_chart_4 Exportin-1 Human There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] This target only has 0 pki data point 5 CHEMBL52229_lig_chart_5 P-glycoprotein 1 Human There should be some charts here, you may need to enable JavaScript!
TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8] This target only has 0 pki data point 6 CHEMBL52229_lig_chart_6 TRPV3 Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibition of 5-lipoxygenase	B	4.44	pIC50	36200	nM	IC50	J. Nat. Prod. (1998) 61: 347-350 [PMID:9544564]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately	B	4.28	pIC50	52500	nM	IC50	J Nat Prod (2017) 80: 2472-2477 [PMID:28885836]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of human COX2 expressed in insect cells using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately	B	4.09	pIC50	81100	nM	IC50	J Nat Prod (2017) 80: 2472-2477 [PMID:28885836]
exportin 1/Exportin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5661] [GtoPdb: 3014] [UniProtKB: O14980]
ChEMBL	Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique	B	5.8	pIC50	1600	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 3717-3720 [PMID:20493693]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Inhibition of P-gp in human LS180 cells after 90 mins by rhodamine123 cell exclusion method	B	4.47	pIC50	34000	nM	IC50	MedChemComm (2014) 5: 1540-1547
TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8]
GtoPdb	-	-	4.4	pIC50	-	-	-	Mol. Pharmacol. (2018) 94: 1164-1173 [PMID:30108138]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]