ChEMBL ligand: CHEMBL2144065
diacylglycerol lipase α in Human [GtoPdb: 1396] [UniProtKB: Q9Y4D2] There should be some charts here, you may need to enable JavaScript!
diacylglycerol lipase β in Human [GtoPdb: 1397] [UniProtKB: Q8NCG7] There should be some charts here, you may need to enable JavaScript!
αβ-Hydrolase 6 in Human [GtoPdb: 2919] [UniProtKB: Q9BV23] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
diacylglycerol lipase α in Human [GtoPdb: 1396] [UniProtKB: Q9Y4D2]
GtoPdb	Determined by competitive ABPP using the HT-01 probe for inhibition of recombinant human DAGL-α	-	5.64	pIC50	2300	nM	IC50	Nat Chem Biol (2012) 8: 999-1007 [PMID:23103940]
diacylglycerol lipase β in Human [GtoPdb: 1397] [UniProtKB: Q8NCG7]
GtoPdb	As measured by LC-MS substrate assay.	-	7.09	pIC50	82	nM	IC50	Nat Chem Biol (2012) 8: 999-1007 [PMID:23103940]
GtoPdb	Determined by competitive ABPP using the HT-01 probe for inhibition of recombinant human DAGL-β	-	7.4	pIC50	40	nM	IC50	Nat Chem Biol (2012) 8: 999-1007 [PMID:23103940]
αβ-Hydrolase 6 in Human [GtoPdb: 2919] [UniProtKB: Q9BV23]
GtoPdb	-	-	7.8	pIC50	16	nM	IC50	Nat Chem Biol (2012) 8: 999-1007 [PMID:23103940]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]