SC-236 [Ligand Id: 10242] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL282093 (SC-58236) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX1 | B | 4.5 | pIC50 | 31400 | nM | IC50 | J Nat Prod (2002) 65: 163-169 [PMID:11858749] |
| ChEMBL | In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1) | B | 4.75 | pIC50 | 17800 | nM | IC50 | J Med Chem (1997) 40: 1347-1365 [PMID:9135032] |
| GtoPdb | - | - | 4.75 | pIC50 | 17800 | nM | IC50 | J Med Chem (1997) 40: 1347-65 [PMID:9135032] |
| GtoPdb | - | - | 4.75 | pIC50 | 17800 | nM | IC50 | J Med Chem (1997) 40: 1347-65 [PMID:9135032] |
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) | B | 4.75 | pIC50 | 17782.79 | nM | IC50 | J Med Chem (2002) 45: 4816-4827 [PMID:12383007] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of human Prostaglandin G/H synthase 2 | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2001) 44: 3223-3230 [PMID:11563921] |
| ChEMBL | Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees. | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 267-270 [PMID:11814774] |
| ChEMBL | In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2) | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1997) 40: 1347-1365 [PMID:9135032] |
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 |
J Med Chem (1997) 40: 1347-65 [PMID:9135032]; J Biol Chem (1996) 271: 15810-4 [PMID:8663121] |
| ChEMBL | Inhibition of COX2 | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Nat Prod (2002) 65: 163-169 [PMID:11858749] |
| COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] | ||||||||
| ChEMBL | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2002) 45: 4816-4827 [PMID:12383007] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
