FK-881 [Ligand Id: 10241] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3427203 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX1 (unknown origin) | B | 8.3 | pIC50 | 5 | nM | IC50 | ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228] |
| ChEMBL | Inhibition of LPS-induced COX1 in human whole blood assessed as reduction in TXB2 levels by radioimmunoassay | B | 8.31 | pIC50 | 4.9 | nM | IC50 | Eur J Med Chem (2015) 94: 252-264 [PMID:25768707] |
| GtoPdb | - | - | 8.31 | pIC50 | 4.9 | nM | IC50 | Biochem Pharmacol (2011) 82: 746-54 [PMID:21745460] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| GtoPdb | - | - | 5.49 | pIC50 | 3200 | nM | IC50 | Biochem Pharmacol (2011) 82: 746-54 [PMID:21745460] |
| ChEMBL | Inhibition of LPS-induced COX2 in human whole blood assessed as reduction in PGH2 levels by radioimmunoassay | B | 5.49 | pIC50 | 3200 | nM | IC50 | Eur J Med Chem (2015) 94: 252-264 [PMID:25768707] |
| ChEMBL | Inhibition of COX2 (unknown origin) | B | 5.49 | pIC50 | 3200 | nM | IC50 | ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
