AZ2 [Ligand Id: 10233] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | 3981 | nM | IC50 | Nat Chem Biol (2019) 15: 348-357 [PMID:30718815] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
| GtoPdb | - | - | 4.5 | pIC50 | 31622 | nM | IC50 | Nat Chem Biol (2019) 15: 348-357 [PMID:30718815] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
| GtoPdb | - | - | 6.7 | pKi | 199 | nM | Ki | Nat Chem Biol (2019) 15: 348-357 [PMID:30718815] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
| GtoPdb | Binding affinity determined by SPR using a two-step binding model. | - | 8.65 | pKd | 2.24 | nM | Kd | Nat Chem Biol (2019) 15: 348-357 [PMID:30718815] |
| GtoPdb | Biochemical assay using purified protein expressed from a construct containing C-terminal 6-His-tagged human p110&gamma (S144-A1102). | - | 9.46 | pIC50 | 0.35 | nM | IC50 | Nat Chem Biol (2019) 15: 348-357 [PMID:30718815] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
