DDR1/2 inhibitor 5n [Ligand Id: 10105] activity data from GtoPdb

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  • neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629]
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  • neurotrophic receptor tyrosine kinase 2 in Human [GtoPdb: 1818] [UniProtKB: Q16620]
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  • neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288]
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  • EPH receptor A2 in Human [GtoPdb: 1822] [UniProtKB: P29317]
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  • EPH receptor A7 in Human [GtoPdb: 1827] [UniProtKB: Q15375]
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  • EPH receptor A8 in Human [GtoPdb: 1828] [UniProtKB: P29322]
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  • EPH receptor B2 in Human [GtoPdb: 1831] [UniProtKB: P29323]
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  • TEK receptor tyrosine kinase in Human [GtoPdb: 1842] [UniProtKB: Q02763]
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  • discoidin domain receptor tyrosine kinase 1 in Human [GtoPdb: 1843] [UniProtKB: Q08345]
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  • discoidin domain receptor tyrosine kinase 2 in Human [GtoPdb: 1844] [UniProtKB: Q16832]
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519]
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  • LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
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  • serine/threonine kinase 10 in Human [GtoPdb: 2211] [UniProtKB: O94804]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629]
GtoPdb - - 7 pKd 100 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
neurotrophic receptor tyrosine kinase 2 in Human [GtoPdb: 1818] [UniProtKB: Q16620]
GtoPdb - - 7.96 pKd 11 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288]
GtoPdb - - 8.03 pKd 9.3 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
EPH receptor A2 in Human [GtoPdb: 1822] [UniProtKB: P29317]
GtoPdb - - 6.59 pKd 260 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
EPH receptor A7 in Human [GtoPdb: 1827] [UniProtKB: Q15375]
GtoPdb - - 6.7 pKd 200 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
EPH receptor A8 in Human [GtoPdb: 1828] [UniProtKB: P29322]
GtoPdb - - 7.1 pKd 79 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
EPH receptor B2 in Human [GtoPdb: 1831] [UniProtKB: P29323]
GtoPdb - - 6.59 pKd 260 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
TEK receptor tyrosine kinase in Human [GtoPdb: 1842] [UniProtKB: Q02763]
GtoPdb - - 6.43 pKd 370 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
discoidin domain receptor tyrosine kinase 1 in Human [GtoPdb: 1843] [UniProtKB: Q08345]
GtoPdb - - 8.1 pKd 7.9 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
GtoPdb - - 8.03 pIC50 9.4 nM IC50 J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
discoidin domain receptor tyrosine kinase 2 in Human [GtoPdb: 1844] [UniProtKB: Q16832]
GtoPdb - - 8.1 pKd 8 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
GtoPdb - - 7.69 pIC50 20.4 nM IC50 J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519]
GtoPdb - - 6.31 pIC50 494 nM IC50 J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb - - 6.74 pKd 180 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]
serine/threonine kinase 10 in Human [GtoPdb: 2211] [UniProtKB: O94804]
GtoPdb - - 8 pKd 10 nM Kd J Med Chem (2018) 61: 7977-7990 [PMID:30075624]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.