Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	247	12p13.2	CLEC7A	C-type lectin domain containing 7A
Mouse	1	244	6 F3	Clec7a	C-type lectin domain family 7, member a
Rat	1	235		Clec7a	C-type lectin domain containing 7A
Gene and Protein Information Comments
There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified.

Previous and Unofficial Names

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | CLECSF12 | CD369 | SCARE2 | Beta-glucan receptor BGR | Dendritic cell-associated C-type lectin 1 | C-type lectin domain family 7, member A | C-type lectin domain family 7, member a | C-type lectin domain family 7

Database Links
Alphafold	Q9BXN2 (Hs), Q6QLQ4 (Mm)
CATH/Gene3D	3.10.100.10
ChEMBL Target	CHEMBL2034810 (Hs), CHEMBL2034809 (Mm)
Ensembl Gene	ENSG00000172243 (Hs), ENSMUSG00000079293 (Mm), ENSRNOG00000054251 (Rn)
Entrez Gene	64581 (Hs), 56644 (Mm), 502902 (Rn)
Human Protein Atlas	ENSG00000172243 (Hs)
KEGG Gene	hsa:64581 (Hs), mmu:56644 (Mm), rno:502902 (Rn)
OMIM	606264 (Hs)
Pharos	Q9BXN2 (Hs)
RefSeq Nucleotide	NM_197947 (Hs), NM_020008 (Mm), NM_001173386 (Rn)
RefSeq Protein	NP_922938 (Hs), NP_064392 (Mm), NP_001166857 (Rn)
UniProtKB	Q9BXN2 (Hs), Q6QLQ4 (Mm)
Wikipedia	CLEC7A (Hs)

Agonist Comments

A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2].

Immunopharmacology Comments

Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1].

Cell Type Associations

Immuno Cell Type:  Macrophages & monocytes Comment:  Dectin-1 is widely expressed in macrophage populations. References:  1

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Antigen presentation

Immuno Process:  T cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Immuno Process:  Chemotaxis & migration

Immuno Process:  Cytokine production & signalling

General Comments
Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).