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Melanocortin receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [4]) are activated by members of the melanocortin family (α-MSH (POMC, P01189), β-MSH (POMC, P01189) and γ-MSH (POMC, P01189) forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH (POMC, P01189)). Endogenous antagonists include agouti (ASIP, P42127) and agouti-related protein (AGRP, O00253). ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test, whilst NDP-MSH was approved by EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development.


Targets of relevance to immunopharmacology are highlighted in blue

MC1 receptor C Show summary » More detailed page

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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Helgi Schiöth, Tung M. Fong, Vanni Caruso, Biao-Xin Chai, Adrian J. L. Clark, Roger D. Cone, Alex N. Eberle, Sadaf Farooqi, Ira Gantz, Carrie Haskell-Luevano, Victor J. Hruby, Kathleen G. Mountjoy, Colin Pouton, Jeffrey B. Tatro, Jarl E. S. Wikberg. Melanocortin receptors. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.