afamelanotide   Click here for help

GtoPdb Ligand ID: 1324

Synonyms: α-NDP-MSH | [Nle4,dPhe7]α-MSH | CUV-1647 | CUV1647 | NDP-MSH | Scenesse®
Approved drug
afamelanotide is an approved drug (EMA (2014), FDA (2019))
Compound class: Peptide or derivative
Comment: Afamelanotide is a synthetic analogue of α-MSH, and is a first-in-class clinically used non-selective MC receptor agonist. It is used for certain dematological applications [5-6].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)N)C(C)C)CCCCN)Cc1c[nH]c2c1cccc2)CCCNC(=N)N)Cc1ccccc1)Cc1[nH]cnc1)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C)CO)Cc1ccc(cc1)O)CO
Isomeric SMILES CCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N)C(C)C)CCCCN)Cc1c[nH]c2c1cccc2)CCCNC(=N)N)Cc1ccccc1)Cc1[nH]cnc1)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CO)Cc1ccc(cc1)O)CO
InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1
InChI Key UAHFGYDRQSXQEB-LEBBXHLNSA-N
Classification Click here for help
Compound class Peptide or derivative
Approved drug? Yes (EMA (2014), FDA (2019))
International Nonproprietary Names Click here for help
INN number INN
9010 afamelanotide
Synonyms Click here for help
α-NDP-MSH | [Nle4,dPhe7]α-MSH | CUV-1647 | CUV1647 | NDP-MSH | Scenesse®
Database Links Click here for help
Specialist databases
GPCRdb Ligand afamelanotide
Other databases
CAS Registry No. 75921-69-6 (source: Scifinder)
ChEMBL Ligand CHEMBL441738
GtoPdb PubChem SID 135652322
PubChem CID 16197727
Search Google for chemical match using the InChIKey UAHFGYDRQSXQEB-LEBBXHLNSA-N
Search Google for chemicals with the same backbone UAHFGYDRQSXQEB
Search PubMed clinical trials afamelanotide
Search PubMed titles afamelanotide
Search PubMed titles/abstracts afamelanotide
UniChem Compound Search for chemical match using the InChIKey UAHFGYDRQSXQEB-LEBBXHLNSA-N
UniChem Connectivity Search for chemical match using the InChIKey UAHFGYDRQSXQEB-LEBBXHLNSA-N
Wikipedia Afamelanotide