Top ▲

Protein kinase C (PKC) family C


« Hide More detailed introduction

Protein kinase C is the target for the tumour-promoting phorbol esters, such as tetradecanoyl-β-phorbol acetate (TPA, also known as phorbol 12-myristate 13-acetate).

Classical protein kinase C isoforms: PKCα, PKCβ, and PKCγ are activated by Ca2+ and diacylglycerol, and may be inhibited by GF109203X, calphostin C, Gö 6983, chelerythrine and Ro31-8220.

Novel protein kinase C isoforms: PKCδ, PKCε, PKCη, PKCθ and PKCμ are activated by diacylglycerol and may be inhibited by calphostin C, Gö 6983 and chelerythrine.

Atypical protein kinase C isoforms:PKCι, PKCζ.


Families that contain targets of relevance to immunopharmacology are highlighted in blue

The Kinome image shown here was obtained from Chartier et al. (2013, <a href='' target='_blank'>Figure 4</a>) <a href='' target='_blank'></a> and has been annotated to show the kinases that are targeted by currently approved kinase inhibitor drugs (last updated in April 2018).

Further reading

Show »

How to cite this family page

Database page citation:

Protein kinase C (PKC) family. Accessed on 22/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.