Top ▲
« Hide More detailed introduction
Protein kinase C is the target for the tumour-promoting phorbol esters, such as tetradecanoyl-β-phorbol acetate (TPA, also known as phorbol 12-myristate 13-acetate). Subfamilies of protein kinase C are identified on the basis of sequence similarities, although functional division into the groups of classical protein kinase C isoforms (PKCα, PKCβ, and PKCγ) activated by Ca2+ and diacylglycerol, novel protein kinase C isoforms (PKCδ, PKCε, PKCη, and PKCθ) activated by diacylglycerol and atypical protein kinase C isoforms (PKCι and PKCζ) are useful.
Families that contain targets of relevance to immunopharmacology are highlighted in blue |
|
Database page citation:
Protein kinase C (PKC) family. Accessed on 08/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=286.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.