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Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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3',5'-Cyclic nucleotide phosphodiesterases (PDEs, 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3',5'-cyclic nucleotide (usually cyclic AMP or cyclic GMP). Isobutylmethylxanthine is a nonselective inhibitor with an IC50 value in the millimolar range for all isoforms except PDE 8A, 8B and 9A. A 2',3'-cyclic nucleotide 3'-phosphodiesterase (E.C. 3.1.4.37 CNPase) activity is associated with myelin formation in the development of the CNS.

Enzymes

1308
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Targets of relevance to immunopharmacology are highlighted in blue

PDE1A (phosphodiesterase 1A) C Show summary »

PDE1B (phosphodiesterase 1B) C Show summary »

PDE1C (phosphodiesterase 1C) C Show summary »

PDE2A (phosphodiesterase 2A) C Show summary »

PDE3A (phosphodiesterase 3A) C Show summary » More detailed page go icon to follow link

PDE3B (phosphodiesterase 3B) C Show summary »

PDE4A (phosphodiesterase 4A) C Show summary » More detailed page go icon to follow link

PDE4B (phosphodiesterase 4B) C Show summary » More detailed page go icon to follow link

PDE4C (phosphodiesterase 4C) C Show summary » More detailed page go icon to follow link

PDE4D (phosphodiesterase 4D) C Show summary » More detailed page go icon to follow link

PDE5A (phosphodiesterase 5A) C Show summary » More detailed page go icon to follow link

PDE6A (phosphodiesterase 6A) C Show summary »

PDE6B (phosphodiesterase 6B) C Show summary » More detailed page go icon to follow link

PDE6C (phosphodiesterase 6C) C Show summary »

PDE6D (phosphodiesterase 6D) C Show summary »

PDE6G (phosphodiesterase 6G) C Show summary »

PDE6H (phosphodiesterase 6H) C Show summary »

PDE7A (phosphodiesterase 7A) C Show summary »

PDE7B (phosphodiesterase 7B) C Show summary » More detailed page go icon to follow link

PDE8A (phosphodiesterase 8A) C Show summary » More detailed page go icon to follow link

PDE8B (phosphodiesterase 8B) C Show summary »


Target Id 1308
Nomenclature phosphodiesterase 8B
Common abbreviation PDE8B
Previous and unofficial names high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Genes PDE8B (Hs), Pde8b (Mm), Pde8b (Rn)
Ensembl ID ENSG00000113231 (Hs), ENSMUSG00000021684 (Mm), ENSRNOG00000010280 (Rn)
UniProtKB AC O95263 (Hs), E9Q4S1 (Mm)
EC number
3.1.4.17
Rank order of affinity cyclic AMP >> cyclic GMP  [16]
Selective inhibitors
dipyridamole pIC50 4.3 [16]

PDE9A (phosphodiesterase 9A) C Show summary »

PDE10A (phosphodiesterase 10A) C Show summary » More detailed page go icon to follow link

PDE11A (phosphodiesterase 11A) C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.