SLC25 family of mitochondrial transporters | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters

SLC25 family of mitochondrial transporters C

Contents

Overview
Subfamilies
Further reading
How to cite this family page

Overview

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Mitochondrial transporters are nuclear-encoded proteins, which convey solutes across the inner mitochondrial membrane. Topological modelling suggests homodimeric transporters, each with six TM segments and termini in the cytosol.

Subfamilies

Families that contain targets of relevance to immunopharmacology are highlighted in blue
Mitochondrial di- and tri-carboxylic acid transporter subfamily C Mitochondrial amino acid transporter subfamily C Mitochondrial phosphate transporters C Mitochondrial nucleotide transporter subfamily C Mitochondrial uncoupling proteins C Miscellaneous SLC25 mitochondrial transporters C

Further reading

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* Key recommended reading is highlighted with an asterisk

* Baffy G. (2017) Mitochondrial uncoupling in cancer cells: Liabilities and opportunities. Biochim Biophys Acta, 1858 (8): 655-664. [PMID:28088333]

Bertholet AM, Kirichok Y. (2017) UCP1: A transporter for H⁺ and fatty acid anions. Biochimie, 134: 28-34. [PMID:27984203]

Cioffi F, Senese R, de Lange P, Goglia F, Lanni A, Lombardi A. (2009) Uncoupling proteins: a complex journey to function discovery. Biofactors, 35 (5): 417-28. [PMID:19626697]

* Clémençon B, Babot M, Trézéguet V. (2013) The mitochondrial ADP/ATP carrier (SLC25 family): pathological implications of its dysfunction. Mol Aspects Med, 34 (2-3): 485-93. [PMID:23506884]

Gnoni GV, Priore P, Geelen MJ, Siculella L. (2009) The mitochondrial citrate carrier: metabolic role and regulation of its activity and expression. IUBMB Life, 61 (10): 987-94. [PMID:19787704]

Gutiérrez-Aguilar M, Baines CP. (2013) Physiological and pathological roles of mitochondrial SLC25 carriers. Biochem J, 454 (3): 371-86. [PMID:23988125]

Halestrap AP. (2009) What is the mitochondrial permeability transition pore?. J Mol Cell Cardiol, 46 (6): 821-31. [PMID:19265700]

Jezek P, Jabůrek M, Garlid KD. (2010) Channel character of uncoupling protein-mediated transport. FEBS Lett, 584 (10): 2135-41. [PMID:20206627]

* Kunji ERS, King MS, Ruprecht JJ, Thangaratnarajah C. (2020) The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology. Physiology (Bethesda), 35 (5): 302-327. [PMID:32783608]

Leung AW, Halestrap AP. (2008) Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim Biophys Acta, 1777 (7-8): 946-52. [PMID:18407825]

Monné M, Palmieri F. (2014) Antiporters of the mitochondrial carrier family. Curr Top Membr, 73: 289-320. [PMID:24745987]

Palmieri F. (2004) The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch, 447 (5): 689-709. [PMID:14598172]

Palmieri F. (2013) The mitochondrial transporter family SLC25: identification, properties and physiopathology. Mol Aspects Med, 34 (2-3): 465-84. [PMID:23266187]

Palmieri F. (2014) Mitochondrial transporters of the SLC25 family and associated diseases: a review. J Inherit Metab Dis, 37 (4): 565-75. [PMID:24797559]

* Palmieri F, Scarcia P, Monné M. (2020) Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review. Biomolecules, 10 (4). DOI: 10.3390/biom10040655 [PMID:32340404]

* Rochette L, Meloux A, Zeller M, Malka G, Cottin Y, Vergely C. (2020) Mitochondrial SLC25 Carriers: Novel Targets for Cancer Therapy. Molecules, 25 (10). DOI: 10.3390/molecules25102417 [PMID:32455902]

* Ruprecht JJ, Kunji ERS. (2020) The SLC25 Mitochondrial Carrier Family: Structure and Mechanism. Trends Biochem Sci, 45 (3): 244-258. [PMID:31787485]

Seifert EL, Ligeti E, Mayr JA, Sondheimer N, Hajnóczky G. (2015) The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease. Biochem Biophys Res Commun, 464 (2): 369-75. [PMID:26091567]

* Taylor EB. (2017) Functional Properties of the Mitochondrial Carrier System. Trends Cell Biol, 27 (9): 633-644. [PMID:28522206]

How to cite this family page

Database page citation:

SLC25 family of mitochondrial transporters. Accessed on 25/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=147.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.