Top ▲
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP. Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified.
ANT1 (Mitochondrial adenine nucleotide translocator 1 / SLC25A4) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
ANT2 (Mitochondrial adenine nucleotide translocator 2 / SLC25A5) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
ANT3 (Mitochondrial adenine nucleotide translocator 3 / SLC25A6) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
ANT4 (Mitochondrial adenine nucleotide translocator 4 / SLC25A31) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
GDC (Graves disease carrier / SLC25A16) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
PMP34 (Peroxisomal membrane protein / SLC25A17) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
DNC (Deoxynucleotide carrier 1 / SLC25A19) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
SAMC1 (S-Adenosylmethionine carrier / SLC25A26) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
SLC25A42 Show summary »« Hide summary
|
||||||||||||||||||||||||||||
APC1 (Mitochondrial phosphate carrier 1 / SLC25A24) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
APC2 (Mitochondrial phosphate carrier 2 / SLC25A23) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
APC3 (Mitochondrial phosphate carrier 3 / SLC25A25) C Show summary »« Hide summary
|
||||||||||||||||||||||||||||
MFTC (MFT / SLC25A32) Show summary »« Hide summary
|
||||||||||||||||||||||||||||
PNC1 / SLC25A33 Show summary »« Hide summary
|
||||||||||||||||||||||||||||
PNC2 (SLC25A36) Show summary »« Hide summary
|
||||||||||||||||||||||||||||
SCaMC-3L / SLC25A41 Show summary »« Hide summary
|
||||||||||||||||||||||||||||
SLC25A43 Show summary »« Hide summary
|
* Key recommended reading is highlighted with an asterisk
* Ruprecht JJ, Kunji ER. (2019) Structural changes in the transport cycle of the mitochondrial ADP/ATP carrier. Curr Opin Struct Biol, 57: 135-144. [PMID:31039524]
* Ruprecht JJ, Kunji ERS. (2021) Structural Mechanism of Transport of Mitochondrial Carriers. Annu Rev Biochem, 90: 535-558. [PMID:33556281]
Database page citation:
Mitochondrial nucleotide transporter subfamily. Accessed on 07/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License