Mitochondrial nucleotide transporter subfamily | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters
Mitochondrial nucleotide transporter subfamily

Mitochondrial nucleotide transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP. Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

ANT1 (Mitochondrial adenine nucleotide translocator 1 / SLC25A4) C Show summary »« Hide summary

Target Id

1062

Nomenclature

Mitochondrial adenine nucleotide translocator 1

Systematic nomenclature

SLC25A4

Common abbreviation

ANT1

Previous and unofficial names

ADP,ATP carrier protein 1 | ADP,ATP carrier protein, heart/skeletal muscle isoform T1 | PEO2 | PEO3 | T1 | ADP/ATP translocase 1 | solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4 | adenine nucleotide translocase-1 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A4 (Hs), Slc25a4 (Mm), Slc25a4 (Rn)

Ensembl ID

ENSG00000151729 (Hs), ENSMUSG00000031633 (Mm), ENSRNOG00000010830 (Rn)

UniProtKB AC

P12235 (Hs), P48962 (Mm), Q05962 (Rn)

Bioparadigms SLC Tables

SLC25A4 (Hs)

RESOLUTE

SLC25A4 (Hs)

Inhibitors

carboxyatractyloside

bongkrek acid

Stoichiometry

ADP^3- (in) : ATP^4- (out)

ANT2 (Mitochondrial adenine nucleotide translocator 2 / SLC25A5) C Show summary »« Hide summary

Target Id	1063
Nomenclature	Mitochondrial adenine nucleotide translocator 2
Systematic nomenclature	SLC25A5
Common abbreviation	ANT2
Previous and unofficial names	2F1 \| T2 \| T3 \| adenine nucleotide translocator 2 fibroblast isoform (ATP-ADP carrier protein) \| solute carrier family 25 member 5 \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 \| solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 \| solute carrier family 25 (mitochondrial carrier
Genes	SLC25A5 (Hs), Slc25a5 (Mm), Slc25a5 (Rn)
Ensembl ID	ENSG00000005022 (Hs), ENSMUSG00000016319 (Mm), ENSRNOG00000039980 (Rn)
UniProtKB AC	P05141 (Hs), P51881 (Mm), Q09073 (Rn)
Bioparadigms SLC Tables	SLC25A5 (Hs)
RESOLUTE	SLC25A5 (Hs)
Stoichiometry	ADP^3- (in) : ATP^4- (out)

ANT3 (Mitochondrial adenine nucleotide translocator 3 / SLC25A6) C Show summary »« Hide summary

Target Id	1064
Nomenclature	Mitochondrial adenine nucleotide translocator 3
Systematic nomenclature	SLC25A6
Common abbreviation	ANT3
Previous and unofficial names	Adenine nucleotide translocator 2 \| ADP,ATP carrier protein 3 \| ADP,ATP carrier protein, isoform T2 \| ANT3Y \| adenine nucleotide translocator), member 6 \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Genes	SLC25A6 (Hs), Slc25a6 (Rn)
Ensembl ID	ENSG00000169100 (Hs), ENSRNOG00000042387 (Rn)
UniProtKB AC	P12236 (Hs)
Bioparadigms SLC Tables	SLC25A6 (Hs)
RESOLUTE	SLC25A6 (Hs)
Stoichiometry	ADP^3- (in) : ATP^4- (out)

ANT4 (Mitochondrial adenine nucleotide translocator 4 / SLC25A31) C Show summary »« Hide summary

Target Id	1065
Nomenclature	Mitochondrial adenine nucleotide translocator 4
Systematic nomenclature	SLC25A31
Common abbreviation	ANT4
Previous and unofficial names	Sperm flagellar energy carrier protein \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator)
Genes	SLC25A31 (Hs), Slc25a31 (Mm), Slc25a31 (Rn)
Ensembl ID	ENSG00000151475 (Hs), ENSMUSG00000069041 (Mm), ENSRNOG00000038398 (Rn)
UniProtKB AC	Q9H0C2 (Hs), Q3V132 (Mm)
Bioparadigms SLC Tables	SLC25A31 (Hs)
RESOLUTE	SLC25A31 (Hs)
Stoichiometry	ADP^3- (in) : ATP^4- (out)

GDC (Graves disease carrier / SLC25A16) C Show summary »« Hide summary

Target Id

1071

Nomenclature

Graves disease carrier

Systematic nomenclature

SLC25A16

Common abbreviation

GDC

Previous and unofficial names

Genes

SLC25A16 (Hs), Slc25a16 (Mm), Slc25a16 (Rn)

Ensembl ID

ENSG00000122912 (Hs), ENSMUSG00000071253 (Mm), ENSRNOG00000000387 (Rn)

UniProtKB AC

P16260 (Hs), Q8C0K5 (Mm), P16261 (Rn)

Bioparadigms SLC Tables

SLC25A16 (Hs)

RESOLUTE

SLC25A16 (Hs)

Substrates

CoA and congeners

Stoichiometry

CoA (in)

PMP34 (Peroxisomal membrane protein / SLC25A17) C Show summary »« Hide summary

Target Id

1072

Nomenclature

Peroxisomal membrane protein

Systematic nomenclature

SLC25A17

Common abbreviation

PMP34

Previous and unofficial names

peroxisomal membrane protein (34kD) | peroxisomal membrane protein PMP34 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A17 (Hs), Slc25a17 (Mm), Slc25a17 (Rn)

Ensembl ID

ENSG00000100372 (Hs), ENSMUSG00000022404 (Mm), ENSRNOG00000018920 (Rn)

UniProtKB AC

O43808 (Hs), O70579 (Mm)

Bioparadigms SLC Tables

SLC25A17 (Hs)

RESOLUTE

SLC25A17 (Hs)

Substrates

ADP

ATP

adenosine 5'-monophosphate

Stoichiometry

ATP (in)

DNC (Deoxynucleotide carrier 1 / SLC25A19) C Show summary »« Hide summary

Target Id

1073

Nomenclature

Deoxynucleotide carrier 1

Systematic nomenclature

SLC25A19

Common abbreviation

DNC

Previous and unofficial names

Genes

SLC25A19 (Hs), Slc25a19 (Mm), Slc25a19 (Rn)

Ensembl ID

ENSG00000125454 (Hs), ENSMUSG00000020744 (Mm), ENSRNOG00000003918 (Rn)

UniProtKB AC

Q9HC21 (Hs), Q9DAM5 (Mm)

Bioparadigms SLC Tables

SLC25A19 (Hs)

RESOLUTE

SLC25A19 (Hs)

Substrates

Deoxynucleotide Diphosphates (dNDPs)

Deoxynucleotide Triphosphates (dNTPs)

Dideoxynucleotide Triphosphates (ddNTPs)

Nucleotide Diphosphates (NDPs)

Stoichiometry

dNDP (in) : ATP (out)

SAMC1 (S-Adenosylmethionine carrier / SLC25A26) C Show summary »« Hide summary

Target Id

1074

Nomenclature

S-Adenosylmethionine carrier

Systematic nomenclature

SLC25A26

Common abbreviation

SAMC1

Previous and unofficial names

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 | SAMC | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A26 (Hs), Slc25a26 (Mm), Slc25a26 (Rn)

Ensembl ID

ENSG00000144741 (Hs), ENSMUSG00000045100 (Mm), ENSRNOG00000012831 (Rn)

UniProtKB AC

Q70HW3 (Hs), Q5U680 (Mm)

Bioparadigms SLC Tables

SLC25A26 (Hs)

RESOLUTE

SLC25A26 (Hs)

Substrates

S-adenosyl methionine

SLC25A42 Show summary »« Hide summary

APC1 (Mitochondrial phosphate carrier 1 / SLC25A24) C Show summary »« Hide summary

Target Id	1077
Nomenclature	Mitochondrial phosphate carrier 1
Systematic nomenclature	SLC25A24
Common abbreviation	APC1
Previous and unofficial names	calcium-binding mitochondrial carrier protein SCaMC-1 \| solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 \| solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 \| solute carrier family 25 (mitochondrial carrier
Genes	SLC25A24 (Hs), Slc25a24 (Mm), Slc25a24 (Rn)
Ensembl ID	ENSG00000085491 (Hs), ENSMUSG00000040322 (Mm), ENSRNOG00000020470 (Rn)
UniProtKB AC	Q6NUK1 (Hs), Q8BMD8 (Mm)
Bioparadigms SLC Tables	SLC25A24 (Hs)
RESOLUTE	SLC25A24 (Hs)

APC2 (Mitochondrial phosphate carrier 2 / SLC25A23) C Show summary »« Hide summary

Target Id	1078
Nomenclature	Mitochondrial phosphate carrier 2
Systematic nomenclature	SLC25A23
Common abbreviation	APC2
Previous and unofficial names	APC2 \| calcium-binding mitochondrial carrier protein SCaMC-3 \| solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 \| solute carrier family 25 (mitochondrial carrier; phosphate carrier)
Genes	SLC25A23 (Hs), Slc25a23 (Mm), Slc25a23 (Rn)
Ensembl ID	ENSG00000125648 (Hs), ENSMUSG00000046329 (Mm), ENSRNOG00000047781 (Rn)
UniProtKB AC	Q9BV35 (Hs), Q6GQS1 (Mm)
Bioparadigms SLC Tables	SLC25A23 (Hs)
RESOLUTE	SLC25A23 (Hs)

APC3 (Mitochondrial phosphate carrier 3 / SLC25A25) C Show summary »« Hide summary

Target Id	1079
Nomenclature	Mitochondrial phosphate carrier 3
Systematic nomenclature	SLC25A25
Common abbreviation	APC3
Previous and unofficial names	MCSC \| PCSCL \| ATP-Mg/Pi carrier \| calcium-binding mitochondrial carrier protein SCaMC-2 \| mitochondrial ATP-Mg/Pi carrier protein \| mitochondrial Ca2+-dependent solute carrier \| small calcium-binding mitochondrial carrier protein 2 \| solute carrier family 25 member 25 \| solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 \| solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 \| solute carrier family 25 (mitochondrial carrier
Genes	SLC25A25 (Hs), Slc25a25 (Mm), Slc25a25 (Rn)
Ensembl ID	ENSG00000148339 (Hs), ENSMUSG00000026819 (Mm), ENSRNOG00000014338 (Rn)
UniProtKB AC	Q6KCM7 (Hs), A2ASZ8 (Mm), Q8K3P6 (Rn)
Bioparadigms SLC Tables	SLC25A25 (Hs)
RESOLUTE	SLC25A25 (Hs)

MFTC (MFT / SLC25A32) Show summary »« Hide summary

Target Id	1083
Nomenclature	MFT
Systematic nomenclature	SLC25A32
Common abbreviation	MFTC
Previous and unofficial names	MFTC \| mitochondrial folate transporter/carrier \| solute carrier family 25 (mitochondrial folate carrier) , member 32 \| solute carrier family 25 (mitochondrial folate carrier), member 32 \| solute carrier family 25
Genes	SLC25A32 (Hs), Slc25a32 (Mm), Slc25a32 (Rn)
Ensembl ID	ENSG00000164933 (Hs), ENSMUSG00000022299 (Mm), ENSRNOG00000004403 (Rn)
UniProtKB AC	Q9H2D1 (Hs), Q8BMG8 (Mm)
Bioparadigms SLC Tables	SLC25A32 (Hs)
RESOLUTE	SLC25A32 (Hs)

PNC1 / SLC25A33 Show summary »« Hide summary

Target Id	1084
Nomenclature	PNC1
Systematic nomenclature	SLC25A33
Previous and unofficial names	BMSC-MCP \| solute carrier family 25 member 33 \| solute carrier family 25 (pyrimidine nucleotide carrier), member 33 \| solute carrier family 25
Genes	SLC25A33 (Hs), Slc25a33 (Mm), Slc25a33 (Rn)
Ensembl ID	ENSG00000171612 (Hs), ENSMUSG00000028982 (Mm), ENSRNOG00000016949 (Rn)
UniProtKB AC	Q9BSK2 (Hs), Q3TZX3 (Mm)
Bioparadigms SLC Tables	SLC25A33 (Hs)
RESOLUTE	SLC25A33 (Hs)

PNC2 (SLC25A36) Show summary »« Hide summary

Target Id	1087
Systematic nomenclature	SLC25A36
Common abbreviation	PNC2
Previous and unofficial names	solute carrier family 25, member 36 \| solute carrier family 25 (pyrimidine nucleotide carrier ), member 36 \| solute carrier family 25 (pyrimidine nucleotide carrier), member 36 \| solute carrier family 25
Genes	SLC25A36 (Hs), Slc25a36 (Mm), Slc25a36 (Rn)
Ensembl ID	ENSG00000114120 (Hs), ENSMUSG00000032449 (Mm), ENSRNOG00000013802 (Rn)
UniProtKB AC	Q96CQ1 (Hs), Q922G0 (Mm)
Bioparadigms SLC Tables	SLC25A36 (Hs)
RESOLUTE	SLC25A36 (Hs)

SCaMC-3L / SLC25A41 Show summary »« Hide summary

Target Id	1092
Nomenclature	SCaMC-3L
Systematic nomenclature	SLC25A41
Previous and unofficial names	APC4 \| mitochondrial ATP-Mg/Pi carrier protein \| solute carrier family 25 member 41 \| solute carrier family 25
Genes	SLC25A41 (Hs), Slc25a41 (Mm), Slc25a41 (Rn)
Ensembl ID	ENSG00000181240 (Hs), ENSMUSG00000011486 (Mm), ENSRNOG00000048853 (Rn)
UniProtKB AC	Q8N5S1 (Hs), Q8BVN7 (Mm)
Bioparadigms SLC Tables	SLC25A41 (Hs)
RESOLUTE	SLC25A41 (Hs)

SLC25A43 Show summary »« Hide summary

Target Id	1093
Systematic nomenclature	SLC25A43
Previous and unofficial names	solute carrier family 25, member 43 \| solute carrier family 25
Genes	SLC25A43 (Hs), Slc25a43 (Mm)
Ensembl ID	ENSG00000077713 (Hs), ENSMUSG00000037636 (Mm)
UniProtKB AC	Q8WUT9 (Hs), A2A3V2 (Mm)
Bioparadigms SLC Tables	SLC25A43 (Hs)
RESOLUTE	SLC25A43 (Hs)

How to cite this family page

Database page citation:

Mitochondrial nucleotide transporter subfamily. Accessed on 29/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.