Mitochondrial uncoupling proteins | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters
Mitochondrial uncoupling proteins

Mitochondrial uncoupling proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial uncoupling proteins allow dissipation of the mitochondrial proton gradient associated with thermogenesis and regulation of radical formation.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

UCP1 (Uncoupling protein 1 / SLC25A7) C Show summary »« Hide summary

Target Id	1066
Nomenclature	Uncoupling protein 1
Systematic nomenclature	SLC25A7
Common abbreviation	UCP1
Previous and unofficial names	Thermogenin \| mitochondrial brown fat uncoupling protein 1 \| solute carrier family 25 member 7 \| uncoupling protein 1 mitochondrial \| uncoupling protein 1 (mitochondrial, proton carrier) \| uncoupling protein 1 (mitochondrial
Genes	UCP1 (Hs), Ucp1 (Mm), Ucp1 (Rn)
Ensembl ID	ENSG00000109424 (Hs), ENSMUSG00000031710 (Mm), ENSRNOG00000003580 (Rn)
UniProtKB AC	P25874 (Hs), P12242 (Mm), P04633 (Rn)
Bioparadigms SLC Tables	SLC25A7 (Hs)
RESOLUTE	UCP1 (Hs)
Stoichiometry	H⁺ (in)

UCP2 (Uncoupling protein 2 / SLC25A8) C Show summary »« Hide summary

Target Id	1067
Nomenclature	Uncoupling protein 2
Systematic nomenclature	SLC25A8
Common abbreviation	UCP2
Previous and unofficial names	mitochondrial uncoupling protein 2 \| solute carrier family 25 member 8 \| Uncoupling protein 2 mitochondrial \| uncoupling protein 2 (mitochondrial, proton carrier) \| uncoupling protein 2 (mitochondrial
Genes	UCP2 (Hs), Ucp2 (Mm), Ucp2 (Rn)
Ensembl ID	ENSG00000175567 (Hs), ENSMUSG00000033685 (Mm), ENSRNOG00000017854 (Rn)
UniProtKB AC	P55851 (Hs), P70406 (Mm), P56500 (Rn)
Bioparadigms SLC Tables	SLC25A8 (Hs)
RESOLUTE	UCP2 (Hs)
Stoichiometry	H⁺ (in)

UCP3 (Uncoupling protein 3 / SLC25A9) C Show summary »« Hide summary

Target Id	1068
Nomenclature	Uncoupling protein 3
Systematic nomenclature	SLC25A9
Common abbreviation	UCP3
Previous and unofficial names	mitochondrial uncoupling protein 3 \| solute carrier family 25 member 9 \| Uncoupling protein 3 mitochondrial \| uncoupling protein 3 (mitochondrial, proton carrier) \| uncoupling protein 3 (mitochondrial
Genes	UCP3 (Hs), Ucp3 (Mm), Ucp3 (Rn)
Ensembl ID	ENSG00000175564 (Hs), ENSMUSG00000032942 (Mm), ENSRNOG00000017716 (Rn)
UniProtKB AC	P55916 (Hs), P56501 (Mm), P56499 (Rn)
Bioparadigms SLC Tables	SLC25A9 (Hs)
RESOLUTE	UCP3 (Hs)
Stoichiometry	H⁺ (in)

UCP4 (Uncoupling protein 4 / SLC25A27) C Show summary »« Hide summary

Target Id	1069
Nomenclature	Uncoupling protein 4
Systematic nomenclature	SLC25A27
Common abbreviation	UCP4
Previous and unofficial names	mitochondrial uncoupling protein 4 \| solute carrier family 25, member 27 \| uncoupling protein UCP-4 \| solute carrier family 25
Genes	SLC25A27 (Hs), Slc25a27 (Mm), Slc25a27 (Rn)
Ensembl ID	ENSG00000153291 (Hs), ENSMUSG00000023912 (Mm), ENSRNOG00000010592 (Rn)
UniProtKB AC	O95847 (Hs)
Bioparadigms SLC Tables	SLC25A27 (Hs)
RESOLUTE	SLC25A27 (Hs)
Stoichiometry	H⁺ (in)

UCP5 (Uncoupling protein 5 / SLC25A14) C Show summary »« Hide summary

Target Id	1070
Nomenclature	Uncoupling protein 5
Systematic nomenclature	SLC25A14
Common abbreviation	UCP5
Previous and unofficial names	BMCP1 \| UCP5 \| brain mitochondrial carrier protein 1 \| solute carrier family 25 (mitochondrial carrier, brain), member 14 \| UCP5L \| UCP5S \| solute carrier family 25 (mitochondrial carrier
Genes	SLC25A14 (Hs), Slc25a14 (Mm), Slc25a14 (Rn)
Ensembl ID	ENSG00000102078 (Hs), ENSMUSG00000031105 (Mm), ENSRNOG00000006871 (Rn)
UniProtKB AC	O95258 (Hs), Q9Z2B2 (Mm)
Bioparadigms SLC Tables	SLC25A14 (Hs)
RESOLUTE	SLC25A14 (Hs)
Stoichiometry	H⁺ (in)

KMCP1 / SLC25A30 C Show summary »« Hide summary

Target Id	1082
Nomenclature	KMCP1
Systematic nomenclature	SLC25A30
Previous and unofficial names	UCP6 \| kidney mitochondrial carrier protein 1 \| solute carrier family 25 member 30 \| solute carrier family 25
Genes	SLC25A30 (Hs), Slc25a30 (Mm), Slc25a30 (Rn)
Ensembl ID	ENSG00000174032 (Hs), ENSMUSG00000022003 (Mm), ENSRNOG00000001052 (Rn)
UniProtKB AC	Q5SVS4 (Hs), Q9CR58 (Mm), Q5PQM9 (Rn)
Bioparadigms SLC Tables	SLC25A30 (Hs)
RESOLUTE	SLC25A30 (Hs)

How to cite this family page

Database page citation:

Mitochondrial uncoupling proteins. Accessed on 03/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=207.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.