Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	13	618	11p14.2	SLC5A12	solute carrier family 5 member 12
Mouse	13	619	2 E3	Slc5a12	solute carrier family 5 (sodium/glucose cotransporter), member 12
Rat	-	-		Slc5a12	solute carrier family 5 member 12

Previous and Unofficial Names

electroneutral sodium monocarboxylate cotransporter | low-affinity sodium-lactate cotransporter | Sodium-coupled monocarboxylate transporter 2 | solute carrier family 5 (sodium/glucose cotransporter), member 12 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 | solute carrier family 5 (sodium/glucose cotransporter)

Database Links
Specialist databases
Bioparadigms SLC Tables	SLC5A12 (Hs)
RESOLUTE	SLC5A12 (Hs)
Other databases
Alphafold	Q1EHB4 (Hs), Q49B93 (Mm)
Ensembl Gene	ENSG00000148942 (Hs), ENSMUSG00000041644 (Mm), ENSRNOG00000028008 (Rn)
Entrez Gene	159963 (Hs), 241612 (Mm), 362188 (Rn)
Human Protein Atlas	ENSG00000148942 (Hs)
KEGG Gene	hsa:159963 (Hs), mmu:241612 (Mm), rno:362188 (Rn)
OMIM	612455 (Hs)
Pharos	Q1EHB4 (Hs)
UniProtKB	Q1EHB4 (Hs), Q49B93 (Mm)
Wikipedia	SLC5A12 (Hs)

Immunopharmacology Comments

Lactate accumulation at sites of inflammation has been shown to elevate SLC5A12 expression on CD4+ T cells and increase lactate uptake by the T cells [1]. In experimental conditions this leads to metabolic reprogramming of CD4+ T cells' effector phenotype which induces increased IL-17 production, which further drives pro-inflammatory processes. This lactate/SLC5A12 reprogramming mechanism has been shown to be amenable to pharmacological modulation in a mouse model of arthritis, and is proposed as a novel therapeutic target for chronic inflammatory disorders.

Cell Type Associations

Immuno Cell Type:  T cells Cell Ontology Term:   CD4-positive, alpha-beta T cell (CL:0000624) Comment:  SLC5A12 expression by CD4+ T cells is elevated by lactate accumulation at the sites of chronic inflammation. References:  1