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Glucose transporter 1

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Target not currently curated in GtoImmuPdb

Target id: 875

Nomenclature: Glucose transporter 1

Abbreviated Name: GLUT1

Systematic Nomenclature: SLC2A1

Family: Class I transporters

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 492 1p34.2 SLC2A1 solute carrier family 2 member 1
Mouse 12 492 4 Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1
Rat 12 492 5q36 Slc2a1 solute carrier family 2 member 1
Previous and Unofficial Names Click here for help
erythrocyte/brain glucose transporter | HepG2 glucose transporter | DYT18 | GLUT | GLUT1 | glucose transporter type 1, erythrocyte/brain | GLUTB | GTG1 | Gtg3 | solute carrier family 2 (facilitated glucose transporter) member 1 | Solute carrier family 2 a 1 (facilitated glucose transporter) brain | solute carrier family 2 member 1 | solute carrier family 2 (facilitated glucose transporter), member 1 | solute carrier family 2 (facilitated glucose transporter)
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC2A1 (Hs)
RESOLUTE SLC2A1 (Hs)
Other databases
Alphafold P11166 (Hs), P17809 (Mm), P11167 (Rn)
ChEMBL Target CHEMBL2535 (Hs), CHEMBL5214 (Rn)
Ensembl Gene ENSG00000117394 (Hs), ENSMUSG00000028645 (Mm), ENSRNOG00000007284 (Rn)
Entrez Gene 6513 (Hs), 20525 (Mm), 24778 (Rn)
Human Protein Atlas ENSG00000117394 (Hs)
KEGG Gene hsa:6513 (Hs), mmu:20525 (Mm), rno:24778 (Rn)
OMIM 138140 (Hs)
Pharos P11166 (Hs)
UniProtKB P11166 (Hs), P17809 (Mm), P11167 (Rn)
Wikipedia SLC2A1 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 30 [PMID: 22468970] Small molecule or natural product Hs Negative 5.7 pIC50 9
⤷ pIC50 5.7 (IC50 2x10-6 M) [9]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Childhood absence epilepsy
Disease Ontology: DOID:1825
Orphanet: ORPHA64280
Disease:  Dystonia 9; DYT9
Synonyms: Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity [Orphanet: ORPHA53583]
OMIM: 601042
Orphanet: ORPHA53583
Disease:  Epilepsy, idiopathic generalized, susceptibility to, 12; EIG12
Synonyms: Idiopathic generalized epilepsy [Disease Ontology: DOID:1827]
Disease Ontology: DOID:1827
OMIM: 614847
Disease:  GLUT1 deficiency syndrome 1; GLUT1DS1
Synonyms: Encephalopathy due to GLUT1 deficiency [Orphanet: ORPHA71277]
OMIM: 606777
Orphanet: ORPHA71277
Disease:  GLUT1 deficiency syndrome 2; GLUT1DS2
Synonyms: Paroxysmal exertion-induced dyskinesia [Orphanet: ORPHA98811]
OMIM: 612126
Orphanet: ORPHA98811
General Comments
GLUT1 overexpression is associated with aberant glucose transport observed in many types of cancer cells [1,7,10], may enhance metastasis [5], and is often a marker of poor prognosis [3-4,8,10]. GLUT1 overexpression allows these cells to survive in hypoxic microenvironments [2,6]. GLUT1 inhibitors can cause apoptotic death in cancer cells whilst sparing normal cells, making GLUT1 a molecular target for drug discovery.

References

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1. Brown RS, Wahl RL. (1993) Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer, 72 (10): 2979-85. [PMID:8221565]

2. Calvo MB, Figueroa A, Pulido EG, Campelo RG, Aparicio LA. (2010) Potential role of sugar transporters in cancer and their relationship with anticancer therapy. Int J Endocrinol, 2010. [PMID:20706540]

3. Furudoi A, Tanaka S, Haruma K, Yoshihara M, Sumii K, Kajiyama G, Shimamoto F. (2001) Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma. Oncology, 60 (2): 162-9. [PMID:11244332]

4. Haber RS, Rathan A, Weiser KR, Pritsker A, Itzkowitz SH, Bodian C, Slater G, Weiss A, Burstein DE. (1998) GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer, 83 (1): 34-40. [PMID:9655290]

5. Koch A, Lang SA, Wild PJ, Gantner S, Mahli A, Spanier G, Berneburg M, Müller M, Bosserhoff AK, Hellerbrand C. (2015) Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget, 6 (32): 32748-60. [PMID:26293674]

6. Macheda ML, Rogers S, Best JD. (2005) Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol, 202 (3): 654-62. [PMID:15389572]

7. Rudlowski C, Becker AJ, Schroder W, Rath W, Büttner R, Moser M. (2003) GLUT1 messenger RNA and protein induction relates to the malignant transformation of cervical cancer. Am J Clin Pathol, 120 (5): 691-8. [PMID:14608894]

8. Saigusa S, Toiyama Y, Tanaka K, Okugawa Y, Fujikawa H, Matsushita K, Uchida K, Inoue Y, Kusunoki M. (2012) Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy. Surg Today, 42 (5): 460-9. [PMID:22072148]

9. Wang D, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. (2012) Development of a novel class of glucose transporter inhibitors. J Med Chem, 55 (8): 3827-36. [PMID:22468970]

10. Younes M, Brown RW, Stephenson M, Gondo M, Cagle PT. (1997) Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer, 80 (6): 1046-51. [PMID:9305704]

How to cite this page

Class I transporters: Glucose transporter 1. Last modified on 20/10/2015. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=875.