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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 770

Nomenclature: ABCB3

Abbreviated Name: TAP2

Systematic Nomenclature: ABCB3

Family: ABCB subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 9 686 6p21.32 TAP2 transporter 2, ATP binding cassette subfamily B member
Mouse 9 702 17 17.98 cM Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Rat 9 703 20p12 Tap2 transporter 2, ATP binding cassette subfamily B member
Previous and Unofficial Names Click here for help
Antigen peptide transporter 2 (APT2) | peptide supply factor 2 (PSF-2) | Peptide transporter TAP2 | ATP-binding cassette sub-family B member 3 | Cim | Transporter 2 ABC (ATP binding cassette) | Ham2 | MTP2 | peptide transporter involved in antigen processing 2 | RING11 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | transporter 2 | transporter 2, ATP binding cassette subfamily B member
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
TAP1 (ABCB2) and TAP2 (ABCB3) form a transporter that plays an important role in antigen presentation by major histocompatibility complex class I (MHCI) molecules in the adaptive immune response [1].
Immuno Process Associations
Immuno Process:  Antigen presentation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Inflammation


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1. Seyffer F, Tampé R. (2015) ABC transporters in adaptive immunity. Biochim Biophys Acta, 1850 (3): 449-60. [PMID:24923865]


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