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ABCB subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [4].

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

MDR1, PGP1 (ABCB1) C Show summary » More detailed page

TAP1 (ABCB2) C Show summary »

TAP2 (ABCB3) C Show summary » More detailed page

PGY3 (ABCB4) C Show summary »

ABCB5 C Show summary »

MTABC3 (ABCB6) C Show summary »

ABC7 (ABCB7) C Show summary »

MABC1 (ABCB8) C Show summary »

TAPL (ABCB9) C Show summary »

MTABC2 (ABCB10) C Show summary »

ABC16 (ABCB11) C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.