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Kv5.1

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Target not currently curated in GtoImmuPdb

Target id: 555

Nomenclature: Kv5.1

Family: Voltage-gated potassium channels (Kv)

Contents:

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 494 2p25.1 KCNF1 potassium voltage-gated channel modifier subfamily F member 1 4
Mouse 6 1 493 12 A1.1 Kcnf1 potassium voltage-gated channel, subfamily F, member 1
Rat 6 1 505 6q16 Kcnf1 potassium voltage-gated channel modifier subfamily F member 1
Previous and Unofficial Names Click here for help
IK8 | KH1 | KCNF | potassium channel, voltage gated modifier subfamily F, member 1 | potassium channel, voltage-gated modifier subfamily F, member 1 | potassium voltage-gated channel
Database Links Click here for help
Alphafold Q9H3M0 (Hs), Q7TSH7 (Mm)
Ensembl Gene ENSG00000162975 (Hs), ENSMUSG00000051726 (Mm), ENSRNOG00000024310 (Rn)
Entrez Gene 3754 (Hs), 382571 (Mm), 298908 (Rn)
Human Protein Atlas ENSG00000162975 (Hs)
KEGG Gene hsa:3754 (Hs), mmu:382571 (Mm), rno:298908 (Rn)
OMIM 603787 (Hs)
Pharos Q9H3M0 (Hs)
RefSeq Nucleotide NM_002236 (Hs), NM_201531 (Mm), NM_001169104 (Rn)
RefSeq Protein NP_002227 (Hs), NP_963289 (Mm), NP_001162575 (Rn)
UniProtKB Q9H3M0 (Hs), Q7TSH7 (Mm)
Wikipedia KCNF1 (Hs)
Ion Selectivity and Conductance Click here for help
Species:  None
Macroscopic current rectification:  Modifier
References: 
Tissue Distribution Click here for help
Urinary bladder smooth muscle myocytes.
Species:  Mouse
Technique:  RT-PCR
References:  5
Heart.
Species:  Rat
Technique:  Northern Blot
References:  1,5
Skeletal muscle.
Species:  Rat
Technique:  Northern Blot
References:  1,5
Liver, kidney, pancreas.
Species:  Rat
Technique:  Northern Blot
References:  1,5
Brain: deeper cortical laters, piriform cortex, olfactory tubercule, medial habenular nucleus, medial amygdaloid nuclei, lateral amygdaloid area > hippocampus, dentate gyrus, zona incerta.
Species:  Rat
Technique:  In situ hybridisation
References:  1,5
Functional Assays Click here for help
Voltage-clamp of KV2.1 and KV5.1 heteromultimers expressed in Xenopus oocytes.
Species:  Rat
Tissue:  Xenopus laevis oocytes.
Response measured:  Modulation of KV2.1 deactivation and inactivation.
References:  2
Physiological Functions Click here for help
Modifies the gating properties of KV2.1 and KV2.2 channels.
Species:  Rat
Tissue:  Heteromultimers with KV2 subunits.
References:  2-3
Biologically Significant Variant Comments
A total of 105 SNPs have been identified in human KCNF1. For more information see the entry on GeneCards.
General Comments
KV5.1 has no function on its own, but has important modulatory actions on KV2 channels [2-3].

References

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1. Drewe JA, Verma S, Frech G, Joho RH. (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J Neurosci, 12 (2): 538-48. [PMID:1740690]

2. Kramer JW, Post MA, Brown AM, Kirsch GE. (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Am J Physiol, 274 (6 Pt 1): C1501-10. [PMID:9696692]

3. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J Biol Chem, 272 (39): 24371-9. [PMID:9305895]

4. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y. (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun, 241 (3): 675-81. [PMID:9434767]

5. Verma-Kurvari S, Border B, Joho RH. (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res Mol Brain Res, 46 (1-2): 54-62. [PMID:9191078]

Contributors

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How to cite this page

Attali B, Chandy KG, Giese MH, Grissmer S, Gutman GA, Jan LY, Lazdunski M, Mckinnon D, Nerbonne J, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Trimmer JS, Wang X. Voltage-gated potassium channels (Kv) in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F81/2023.1.