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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.
Kv1.1 C
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Kv1.2 C
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Kv1.3
C
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Kv1.4 C
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Kv1.5 C
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Kv1.6 C
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Kv1.7 C
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Kv1.8 C
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Kv2.1 C
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Kv2.2 C
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Kv3.1 C
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Kv3.2 C
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Kv3.3 C
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Kv3.4 C
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Kv4.1 C
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Kv4.2 C
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Kv4.3 C
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Kv5.1 C
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Kv6.1 C
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Kv6.2 C
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Kv6.3 C
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Kv6.4 C
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Kv7.1 C
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Kv7.2 C
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Kv7.3 C
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Kv7.4 C
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Kv7.5 C
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Kv8.1 C
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Kv8.2 C
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Kv9.1 C
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Kv9.2 C
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Kv9.3 C
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Kv10.1 C
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Kv10.2 C
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Kv11.1 C
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Kv11.2 C
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Kv11.3 C
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Kv12.1 C
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Kv12.2 C
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Kv12.3 C
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Subcommittee members:
Lily Y. Jan (Chairperson)
Bernard Attali
Jeanne Nerbonne
Michael C. Sanguinetti
James S. Trimmer |
Other contributors:
K. George Chandy
M. Hunter Giese
Stephan Grissmer
George A. Gutman
Michel Lazdunski
David Mckinnon
Luis A. Pardo
Gail A. Robertson
Bernardo Rudy
Walter Stühmer
Xiaoliang Wang |
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Ion channels. Br J Pharmacol. 176 Issue S1: S142-228.
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