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DNA gyrase subunit A

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Target not currently curated in GtoImmuPdb

Target id: 3217

Nomenclature: DNA gyrase subunit A

Family: Bacterial protein targets

Contents:

Quaternary Structure: Complexes
DNA gyrase
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Escherichia coli - 875 gyrA DNA gyrase subunit A
Database Links Click here for help
Alphafold P0AES4 (E.coli)
ChEMBL Target CHEMBL1858 (E.coli)
Entrez Gene 946614 (E.coli)
RefSeq Protein NP_416734 (E.coli)
UniProtKB P0AES4 (E.coli)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  59KDA fragment of gyrase A from E.coli
PDB Id:  1ab4
Resolution:  2.8Å
Species:  Escherichia coli
References:  2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ofloxacin Small molecule or natural product Approved drug E.coli - 5.5 pIC50 1
⤷ pIC50 5.5 (IC50 3.5x10-6 M) [1]
Description: DNA-supercoiling assay
General Comments
DNA gyrase subunit A is comprised of an N-terminal domain (59-64 kDa) involved in DNA cleavage and ligation, and a C-terminal domain (33 kDa) involved in DNA-protein interactions [3].

References

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1. Barnard FM, Maxwell A. (2001) Interaction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87). Antimicrob Agents Chemother, 45 (7): 1994-2000. [PMID:11408214]

2. Morais Cabral JH, Jackson AP, Smith CV, Shikotra N, Maxwell A, Liddington RC. (1997) Crystal structure of the breakage-reunion domain of DNA gyrase. Nature, 388 (6645): 903-6. [PMID:9278055]

3. Reece RJ, Maxwell A. (1989) Tryptic fragments of the Escherichia coli DNA gyrase A protein. J Biol Chem, 264 (33): 19648-53. [PMID:2555327]

How to cite this page

Bacterial protein targets: DNA gyrase subunit A. Last modified on 28/04/2023. Accessed on 27/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3217.