Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	254	7q22.1	ORAI2	ORAI calcium release-activated calcium modulator 2
Mouse	4	250	5 G2	Orai2	ORAI calcium release-activated calcium modulator 2
Rat	4	-	12q12	Orai2	ORAI calcium release-activated calcium modulator 2

Previous and Unofficial Names

CAP-binding protein complex interacting protein 2 | CBCIP2 | TMEM142B

Database Links
Alphafold	Q96SN7 (Hs), Q8BH10 (Mm)
ChEMBL Target	CHEMBL4888450 (Hs)
Ensembl Gene	ENSG00000160991 (Hs), ENSMUSG00000039747 (Mm), ENSRNOG00000001427 (Rn)
Entrez Gene	80228 (Hs), 304592 (Rn)
Human Protein Atlas	ENSG00000160991 (Hs)
KEGG Gene	hsa:80228 (Hs), rno:304592 (Rn)
OMIM	610929 (Hs)
Pharos	Q96SN7 (Hs)
RefSeq Nucleotide	NM_032831 (Hs), NM_178751 (Mm), NM_001170403 (Rn)
RefSeq Protein	NP_001119812 (Hs), NP_848866 (Mm), NP_001163874 (Rn)
UniProtKB	Q96SN7 (Hs), Q8BH10 (Mm)
Wikipedia	ORAI2 (Hs)

Download all structure-activity data for this target as a CSV file

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Voltage-dependent (mV) Reference CM4620 Hs Inhibition 6.1 pIC50 - no 4 ⤷ pIC50 6.1 (IC50 8.95x10-7 M) [4] Not voltage dependent Description: In vitro inhibition of calcium entry mediated by Orai2/STIM1 CRAC channels. GSK-7975A Hs Inhibition 5.8 pIC50 - no 4 ⤷ pIC50 5.8 (IC50 1.453x10-6 M) [4] Not voltage dependent Description: In vitro inhibition of calcium entry mediated by Orai2/STIM1 CRAC channels.

Immunopharmacology Comments

The ORAI1 and ORAI2 proteins form heteromeric complexes that constitute the pore of Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels mediate store-operated Ca2+ entry (SOCE), a function that is essential for proper T cell function. Evidence indicates that ORAI2 fine-tunes SOCE to modulate the immune response [3]. Mice with double Orai1/Orai2 knockout have severely impaired T cell function and T cell-dependent antiviral immune responses. Conversely, these mice are protected from T cell-mediated autoimmunity and alloimmunity.

Cell Type Associations

Immuno Cell Type:  T cells Comment:  Orai2 (along with Orai1) is involved in T cell -mediated immune responses (demonstrated in mice in vivo). References:  2

Physiological Consequences of Altering Gene Expression
Deletion of Orai2 increases store-operated Ca2+ entry (SOCE) in mouse T cells. Species:  Mouse Tissue:  T cells Technique:  References:  3
Deletion of Orai2 in murine peritoneal mast cells augments endogenous CRAC currents and degranulation. Species:  Mouse Tissue:  Peritoneal mast cells Technique:  Targeted inactivation of the Orai2 gene. References:  1