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Orai channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Orai channels are pore forming proteins which underlie calcium release-activated calcium (CRAC) channels. When calcium is lost from the endoplasmic reticulum, they form complexes with STIM (stromal interaction molecule) proteins to trigger calcium entry following store depletion [1].

Channels and Subunits

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Targets of relevance to immunopharmacology are highlighted in blue

Orai1 C Show summary » More detailed page go icon to follow link

Orai2 C Show summary » More detailed page go icon to follow link

Orai3 C Show summary » More detailed page go icon to follow link

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Further reading

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References

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How to cite this family page

Database page citation:

Orai channels. Accessed on 07/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=977.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. Br J Pharmacol. 178 Suppl 1:S157-S245.