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polyketide synthase Pks13

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Target not currently curated in GtoImmuPdb

Target id: 2950

Nomenclature: polyketide synthase Pks13

Family: Bacterial protein targets

Contents:

Database Links Click here for help
ChEMBL Target CHEMBL4105939 (M. tuberculosis)
UniProtKB I6X8D2 (M. tuberculosis)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM16
PDB Id:  5V3Y
Ligand:  TAM16
Resolution:  1.98Å
Species:  Mycobacterium tuberculosis
References:  1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
TAM16 Small molecule or natural product Primary target of this compound Ligand has a PDB structure M. tuberculosis Inhibition 6.7 pIC50 1
⤷ pIC50 6.7 (IC50 1.9x10-7 M) [1]
General Comments
FAAL32-Pks13 polyketide synthase catalyzes the condensation reaction, which produces α-alkyl β-ketoacids, direct precursors of mycolic acids. This function is carried out by its thioesterase-like domain as a unique mechanism to transfer polyketide synthase products in mycobacteria, hence the focus on this as a drug target [2].

References

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1. Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R et al.. (2017) Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell, 170 (2): 249-259.e25. [PMID:28669536]

2. Gavalda S, Bardou F, Laval F, Bon C, Malaga W, Chalut C, Guilhot C, Mourey L, Daffé M, Quémard A. (2014) The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria. Chem Biol, 21 (12): 1660-9. [PMID:25467124]

How to cite this page

Bacterial protein targets: polyketide synthase Pks13. Last modified on 26/06/2025. Accessed on 01/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2950.