Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	785	1q23.1	IFI16	interferon gamma inducible protein 16
Gene and Protein Information Comments
A second variant of the human gene (NM_005531) is reported to code isoform 2 (NP_005522) [1-2].

Previous and Unofficial Names

PYHIN2 | IFNGIP1

Database Links
Alphafold	Q16666 (Hs)
Ensembl Gene	ENSG00000163565 (Hs)
Entrez Gene	3428 (Hs)
Human Protein Atlas	ENSG00000163565 (Hs)
KEGG Gene	hsa:3428 (Hs)
OMIM	147586 (Hs)
Pharos	Q16666 (Hs)
RefSeq Nucleotide	NM_001206567 (Hs)
RefSeq Protein	NP_001193496 (Hs)
UniProtKB	Q16666 (Hs)
Wikipedia	IFI16 (Hs)

Immunopharmacology Comments

IFI16 is a sensor for cytosolic DNA which induces type I interferon production via activation of the IRF3/NFκB pathway.

Immuno Process Associations

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0140972 negative regulation of AIM2 inflammasome complex assembly IDA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 4 GO processes GO:0001819 positive regulation of cytokine production TAS GO:0032731 positive regulation of interleukin-1 beta production IDA GO:0035458 cellular response to interferon-beta IBA GO:0140972 negative regulation of AIM2 inflammasome complex assembly IDA

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes GO:0002218 activation of innate immune response IBA GO:0045824 negative regulation of innate immune response IDA GO:0050727 regulation of inflammatory response IDA GO:0140972 negative regulation of AIM2 inflammasome complex assembly IDA

Immuno Process:  Inflammation GO Annotations:  Associated to 6 GO processes GO:0002218 activation of innate immune response IBA GO:0045824 negative regulation of innate immune response IDA GO:0050727 regulation of inflammatory response IDA GO:0140972 negative regulation of AIM2 inflammasome complex assembly IDA click arrow to show/hide IEA associations GO:0006954 inflammatory response IEA GO:0045087 innate immune response IEA

General Comments
IFI16 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995) [3]. The mouse has 12 IFI16 homologs but none shows 1:1 orthology with the human gene.