Top ▲
Target has curated data in GtoImmuPdb
Target id: 2921
Nomenclature: interferon induced with helicase C domain 1
Abbreviated Name: MDA5
Family: RIG-I-like receptor family
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1025 | 2q24.2 | IFIH1 | interferon induced with helicase C domain 1 | |
Mouse | - | 1025 | 2 C1.3 | Ifih1 | interferon induced with helicase C domain 1 | |
Rat | - | 1027 | 3q21 | Ifih1 | interferon induced with helicase C domain 1 |
Previous and Unofficial Names |
MDA-5 | melanoma differentiation-associated gene 5 |
Database Links | |
Alphafold | Q9BYX4 (Hs), Q8R5F7 (Mm) |
BRENDA | 3.6.4.13 |
ChEMBL Target | CHEMBL4739862 (Hs) |
Ensembl Gene | ENSG00000115267 (Hs), ENSMUSG00000026896 (Mm), ENSRNOG00000006227 (Rn) |
Entrez Gene | 64135 (Hs), 71586 (Mm), 499801 (Rn) |
Human Protein Atlas | ENSG00000115267 (Hs) |
KEGG Enzyme | 3.6.4.13 |
KEGG Gene | hsa:64135 (Hs), mmu:71586 (Mm), rno:499801 (Rn) |
OMIM | 606951 (Hs) |
Pharos | Q9BYX4 (Hs) |
RefSeq Nucleotide | NM_022168 (Hs), NM_001164477 (Mm), NM_001109199 (Rn) |
RefSeq Protein | NP_071451 (Hs), NP_001157949 (Mm), NP_001102669 (Rn) |
UniProtKB | Q9BYX4 (Hs), Q8R5F7 (Mm) |
Wikipedia | IFIH1 (Hs) |
Enzyme Reaction | ||||||||||
|
Immunopharmacology Comments |
MDA5 is an intracellualar RNA sensor. It recognizes longer double-stranded RNA sequences than RIG-1. In autoimmunity, MDA5 has been specifically linked with type I diabetes and anti-MDA5 autoantibodies can be detected in patients with certain connective tissue autoimmune conditions [1-3]. |
1. Ahlers LR, Goodman AG. (2016) Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity. Curr Clin Microbiol Rep, 3 (3): 132-141. [PMID:27857881]
2. Hozumi H, Fujisawa T, Nakashima R, Johkoh T, Sumikawa H, Murakami A, Enomoto N, Inui N, Nakamura Y, Hosono Y et al.. (2016) Comprehensive assessment of myositis-specific autoantibodies in polymyositis/dermatomyositis-associated interstitial lung disease. Respir Med, 121: 91-99. [PMID:27888997]
3. Milam EC, Futran J, Franks Jr AG. (2016) Anti-MDA5 Antibody Dermatomyositis Overlap with Systemic Lupus Erythematosus: A Case Report and Review of the Literature. Open Rheumatol J, 10: 122-128. [PMID:28077979]