Top ▲

RIG-I-like receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

« Hide More detailed introduction

There are three human RIG-I-like receptors (RLRs) which are cytoplasmic pattern recognition receptors (PRRs) of the innate immune system. They detect non-self cytosolic double-stranded RNA species and and 5'-triphosphate single-stranded RNA from various sources and are essential for inducing production of type I interferons, such as IFNβ, type III interferons, and other anti-pathogenic effectors [1-2].

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

RIG-1 (DExD/H-box helicase 58) C Show summary » More detailed page

MDA5 (interferon induced with helicase C domain 1) C Show summary » More detailed page

LGP2 (DExH-box helicase 58) C Show summary » More detailed page

Further reading

Show »

References

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Clare Bryant, Tom P. Monie. RIG-I-like receptor family. Accessed on 22/05/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=940.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.