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Target has curated data in GtoImmuPdb
Target id: 2920
Nomenclature: DExD/H-box helicase 58
Abbreviated Name: RIG-1
Family: RIG-I-like receptor family
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 925 | 9p21.1 | RIGI | RNA sensor RIG-I | |
Mouse | - | 926 | 4 A5 | Rigi | RNA sensor RIG-I | |
Rat | - | 598 | 5q22 | Rig1 | RNA sensor RIG-1 |
Previous and Unofficial Names |
DEAD/H box helicase 58 | DDX58 | Ddx58 | DEXD/H-box helicase 58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | retinoic acid inducible gene I | RNA helicase RIG-I |
Database Links | |
Alphafold | O95786 (Hs), Q6Q899 (Mm) |
BRENDA | 3.6.4.13 |
Ensembl Gene | ENSG00000107201 (Hs), ENSMUSG00000040296 (Mm), ENSRNOG00000006384 (Rn) |
Entrez Gene | 23586 (Hs), 230073 (Mm), 297989 (Rn) |
Human Protein Atlas | ENSG00000107201 (Hs) |
KEGG Enzyme | 3.6.4.13 |
KEGG Gene | hsa:23586 (Hs), mmu:230073 (Mm), rno:297989 (Rn) |
OMIM | 609631 (Hs) |
Pharos | O95786 (Hs) |
RefSeq Nucleotide | NM_014314 (Hs), NM_172689 (Mm), NM_001106645 (Rn) |
RefSeq Protein | NP_055129 (Hs), NP_766277 (Mm), NP_001100115 (Rn) |
UniProtKB | O95786 (Hs), Q6Q899 (Mm) |
Wikipedia | RIGI (Hs) |
Enzyme Reaction | ||||||||||
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Download all structure-activity data for this target as a CSV file
Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
RIG-I is an intracellular sensor that responds to viral nucleic acids and activates downstream signaling, resulting in the induction of the type I interferon response [2]. RIG-I recognizes RNAs from more that 25 viruses and can detect dsRNAs, ssRNAs harboring a 5′-triphosphate and blunt-ended 5′-triphosphate-containing dsRNAs. Dysregulated RIG-I signaling has been associated with autoimmune disorders [2]. |
Immuno Process Associations | ||
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1. Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M et al.. (2022) A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. J Exp Med, 219 (1). [PMID:34757384]
2. Matsumiya T, Stafforini DM. (2010) Function and regulation of retinoic acid-inducible gene-I. Crit Rev Immunol, 30 (6): 489-513. [PMID:21175414]