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DExD/H-box helicase 58

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2920

Nomenclature: DExD/H-box helicase 58

Abbreviated Name: RIG-1

Family: RIG-I-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 925 9p21.1 RIGI RNA sensor RIG-I
Mouse - 926 4 A5 Rigi RNA sensor RIG-I
Rat - 598 5q22 Rig1 RNA sensor RIG-1
Previous and Unofficial Names Click here for help
DEAD/H box helicase 58 | DDX58 | Ddx58 | DEXD/H-box helicase 58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | retinoic acid inducible gene I | RNA helicase RIG-I
Database Links Click here for help
Alphafold
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.6.4.13
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SLR14 Small molecule or natural product Hs Agonist - - 1
[1]
Immunopharmacology Comments
RIG-I is an intracellular sensor that responds to viral nucleic acids and activates downstream signaling, resulting in the induction of the type I interferon response [2]. RIG-I recognizes RNAs from more that 25 viruses and can detect dsRNAs, ssRNAs harboring a 5′-triphosphate and blunt-ended 5′-triphosphate-containing dsRNAs. Dysregulated RIG-I signaling has been associated with autoimmune disorders [2].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Physiological Consequences of Altering Gene Expression Click here for help
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from RIG-1 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by RIG-1 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells.
Species:  Mouse
Tissue:  cDCs, macrophages and fibroblasts,
Technique: 
References: 

References

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1. Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M et al.. (2022) A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. J Exp Med, 219 (1). [PMID:34757384]

2. Matsumiya T, Stafforini DM. (2010) Function and regulation of retinoic acid-inducible gene-I. Crit Rev Immunol, 30 (6): 489-513. [PMID:21175414]

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